ArticleDigestive diseases and sciences2004
Crohn's disease: a two-year prospective study of the association between psychological distress and disease activity.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Minocycline as an Adjunct for the Treatment of Depressive Symptoms: Pilot Randomized Controlled Trial
Prevalence of Neuropsychiatric Manifestations in IBD Patients in Upper Egypt
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Systematic review: the role of psychological stress in inflammatory bowel disease.Alimentary pharmacology & therapeutics · 2022Pooled it
- Assessment of causal link between psychological factors and symptom exacerbation in inflammatory bowel disease: a systematic review utilising Bradford Hill criteria and meta-analysis of prospective cohort studies.Systematic reviews · 2020Pooled it
- Systematic Review: Components of a Comprehensive Geriatric Assessment in Inflammatory Bowel Disease-A Potentially Promising but Often Neglected Risk Stratification.Journal of Crohn's & colitis · 2019Pooled it
- Guideline
- Trial
- Mindfulness Intervention Decreases Frequency and Severity of Flares in Inactive Ulcerative Colitis Patients: Results of a Phase II, Randomized, Placebo-Controlled Trial.Inflammatory bowel diseases · 2022Trial
- Trial
- Investigating Handgrip Strength as a Practical Biomarker for Therapeutic Endpoints and Nutritional Status in Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2026Article
- Empowering healthier lifestyles: patterns of digital tool use, self-efficacy, and affective balance in IBD-patients and a community sample.Frontiers in digital health · 2026Article
- Is (critical) health literacy a key to better psychosomatic functioning in patients with inflammatory bowel disease? Testing a mediation model.Frontiers in psychiatry · 2026Article
- Can current post-traumatic growth models capture the lived experience of life with a fluctuating chronic illness? Towards a new model.British journal of health psychology · 2025Article
- Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.Microorganisms · 2024Article
- Multimodal Prehabilitation for Patients with Crohn's Disease Scheduled for Major Surgery: A Narrative Review.Nutrients · 2024Review
- Sex differences evident in elevated anxiety symptoms in multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis.Frontiers in psychiatry · 2023Article
- Correlation Analysis Between Disease Activity and Anxiety, Depression, Sleep Disturbance, and Quality of Life in Patients with Inflammatory Bowel Disease.Nature and science of sleep · 2023Article
- Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol.BMJ open · 2022Article
- Stressor-Induced Increases in Circulating, but Not Colonic, Cytokines Are Related to Anxiety-like Behavior and Hippocampal Inflammation in a Murine Colitis Model.International journal of molecular sciences · 2022Article
- Depression, anxiety, and stress among inflammatory bowel disease patients during COVID-19: A UK cohort study.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- The Association between Temperament, Chronotype, Depressive Symptoms, and Disease Activity among Patients with Inflammatory Bowel Disease-A Cross-Sectional Pilot Study.Life (Basel, Switzerland) · 2021Article
- Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts.Nature communications · 2021Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our objective was to explore the relationship between psychological distress and subsequent Crohn's disease (CD) activity. Eighteen CD patients were followed prospectively for 2 years at 8- to 12-week intervals. Disease activity was assessed using the Crohn's Disease Activity Index (CDAI). Psychological distress was assessed using the following self-administered questionnaires: Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Beck Hopelessness Scale (BHS), and multiple Holmes Recent Life Changes (RLC) Questionnaires. The effects of psychological distress on current and subsequent CDAI (approximately 8-12 weeks later) were assessed using generalized estimating equations (GEE). The mean CDAI score during follow-up was 138 +/- 86, with a median of 121 (range, 0 to 394). BDI scores (possible range of 0 to 63) were independently associated with CDAI scores simultaneously (beta = 5.64, P = 0.004) and 8-12 weeks later (beta = 6.08, P = 0.004). Higher levels of anxiety, hopelessness, and recent life changes were also suggestive of higher CDAI scores, however, their effects were generally of lesser magnitude and not independent of the influence of depressive symptoms. Levels of depressive symptoms are positively associated with future changes in CDAI. Routine psychological assessment may help to identify patients at higher risk for exacerbation.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.