ArticleDigestive diseases and sciences2004
Screening for hemochromatosis in Turkey.
Article in Digestive diseases and sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- In the presence of autoantibodies and iron overload, do not judge a book by its cover: A case report.Hepatology forum · 2021Article
- Effect of Hereditary Hemochromatosis Gene H63D and C282Y Mutations on Iron Overload in Sickle Cell Disease Patients.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2016Article
- Should we screen for hereditary hemochromatosis in healthy Lebanese: a pilot study.Molecular biology reports · 2012Article
- Frequency of Two Common HFE Gene Mutations (C282Y and H63D) in a Group of Iranian Patients With Cryptogenic Cirrhosis.Hepatitis monthly · 2011Article
- Hereditary haemochromatosis gene (HFE) H63D mutation shows an association with abnormal sperm motility.Molecular biology reports · 2009Article
- HFE gene mutation, chronic liver disease, and iron overload In Turkey.Digestive diseases and sciences · 2007Article
- Article
- Serum iron levels and hepatic iron overload in nonalcoholic steatohepatitis and chronic viral hepatitis.Digestive diseases and sciences · 2005Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we screened 3060 consecutive blood donors for an unbound iron-binding capacity level of <28 microM and then performed HFE mutation analysis in these subjects. Sixty-five of the 75 subjects with a low initial unbound iron-binding capacity (all had normal ferritin levels) came back and only 5 (8%) had a low fasting unbound iron-binding capacity. Mutational analysis revealed H63D heterozygosity in two of five subjects. Four of five subjects had liver biopsy indication and none had increased liver iron. HFE genotyping of 60 subjects with a low initial but normal fasting unbound iron-binding capacity revealed heterozygote H63D in seven (11.6%). No allelic variant of position 282 or 63 was found in three previously diagnosed patients with hereditary hemochromatosis. In conclusion, full phenotypic expression of hereditary hemochromatosis is very rare in Turkey. The absence of HFE mutations in three patients with hereditary hemochromatosis suggests that hereditary hemochromatosis in Turkey occurs without common HFE mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.