ReviewCritical reviews in biomedical engineering2003
Biology on a chip: microfabrication for studying the behavior of cultured cells.
Review in Critical reviews in biomedical engineering, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Teach your microscope how to print: low-cost and rapid-iteration microfabrication for biology.Lab on a chip · 2025Article
- Leveraging microphysiological systems to expedite understanding of host-parasite interactions.PLoS pathogens · 2025Review
- Recent Progress and Challenges of Implantable Biodegradable Biosensors.Micromachines · 2024Review
- Cost-Effective Laboratory Matrix Projection Micro-Lithography System.Micromachines · 2023Article
- Engineered cell culture microenvironments for mechanobiology studies of brain neural cells.Frontiers in bioengineering and biotechnology · 2022Review
- The Development of Biomimetic Aligned Skeletal Muscles in a Fully 3D Printed Microfluidic Device.Biomimetics (Basel, Switzerland) · 2021Article
- Microfluidic and Microscale Assays to Examine Regenerative Strategies in the Neuro Retina.Micromachines · 2020Review
- 100th Anniversary of Macromolecular Science Viewpoint: Re-Engineering Cellular Interfaces with Synthetic Macromolecules Using Metabolic Glycan Labeling.ACS macro letters · 2020Article
- "Chip-on-a-Transwell" Devices for User-Friendly Control of the Microenvironment of Cultured Cells.ACS applied bio materials · 2019Article
- Microfluidic Cell Trapping for Single-Cell Analysis.Micromachines · 2019Article
- A Microfabricated 96-Well 3D Assay Enabling High-Throughput Quantification of Cellular Invasion Capabilities.Scientific reports · 2017Article
- An open-chamber flow-focusing device for focal stimulation of micropatterned cells.Biomicrofluidics · 2016Article
- Co-fabrication of chitosan and epoxy photoresist to form microwell arrays with permeable hydrogel bottoms.Biomaterials · 2016Article
- Neural circuits with long-distance axon tracts for determining functional connectivity.Journal of neuroscience methods · 2014Article
- Revealing neuronal function through microelectrode array recordings.Frontiers in neuroscience · 2014Review
- Micropatterning of ECM Proteins on Glass Substrates to Regulate Cell Attachment and Proliferation.Avicenna journal of medical biotechnology · 2013Article
- Characterization of cell seeding and specific capture of B cells in microbubble well arrays.Biomedical microdevices · 2013Article
- Microwell regulation of pluripotent stem cell self-renewal and differentiation.BioNanoScience · 2012Article
- Matrix nanotopography as a regulator of cell function.The Journal of cell biology · 2012Review
- Microwell device for targeting single cells to electrochemical microelectrodes for high-throughput amperometric detection of quantal exocytosis.Analytical chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The ability to culture cells in vitro has revolutionized hypothesis testing in basic cell and molecular biology research and has become a standard methodology in drug screening and toxicology assays. However, the traditional cell culture methodology--consisting essentially of the immersion of a large population of cells in a homogeneous fluid medium--has become increasingly limiting, both from a fundamental point of view (cells in vivo are surrounded by complex spatiotemporal microenvironments) and from a practical perspective (scaling up the number of fluid handling steps and cell manipulations for high-throughput studies in vitro is prohibitively expensive). Microfabrication technologies have enabled researchers to design, with micrometer control, the biochemical composition and topology of the substrate, the medium composition, as well as the type of neighboring cells surrounding the microenvironment of the cell. In addition, microtechnology is conceptually well suited for the development of fast, low-cost in vitro systems that allow for high-throughput culturing and analysis of cells under large numbers of conditions. Here we review a variety of applications of microfabrication in cell culture studies, with an emphasis on the biology of various cell types.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.