ArticleProceedings of the National Academy of Sciences of the United States of America2004
Endometrial calbindins are critical for embryo implantation: evidence from in vivo use of morpholino antisense oligonucleotides.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 81 citations in OpenAlex.
- Oviduct Transcriptomic Reveals the Regulation of mRNAs and lncRNAs Related to Goat Prolificacy in the Luteal Phase.Animals : an open access journal from MDPI · 2022Article
- Cytochrome P450 26A1 regulates the clusters and killing activity of NK cells during the peri-implantation period.Journal of cellular and molecular medicine · 2022Article
- Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.Frontiers in immunology · 2021Article
- Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.Journal of cellular and molecular medicine · 2019Article
- S100 proteins: An emerging cynosure in pregnancy & adverse reproductive outcome.The Indian journal of medical research · 2018Review
- Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.Journal of cellular and molecular medicine · 2017Article
- Functions of S100 proteins.Current molecular medicine · 2013Review
- TRPV6 and Calbindin-D9k-expression and localization in the bovine uterus and placenta during pregnancy.Reproductive biology and endocrinology : RB&E · 2012Article
- Endometrial epithelial cell modifications in response to embryonic signals in bonnet monkeys (Macaca radiata).Histochemistry and cell biology · 2012Article
- Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats.Reproductive biology and endocrinology : RB&E · 2011Article
- Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle.Reproductive biology and endocrinology : RB&E · 2011Article
- The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation.PloS one · 2010Article
- Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation.Journal of anatomy · 2009Review
- Uterine and placental expression of TRPV6 gene is regulated via progesterone receptor- or estrogen receptor-mediated pathways during pregnancy in rodents.Reproductive biology and endocrinology : RB&E · 2009Article
- Endometrium as an early sensor of in vitro embryo manipulation technologies.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation.Reproductive biology and endocrinology : RB&E · 2009Article
- Molecular mechanism of regulation of the calcium-binding protein calbindin-D9k, and its physiological role(s) in mammals: a review of current research.Journal of cellular and molecular medicine · 2008Review
- Endogenous retroviruses regulate periimplantation placental growth and differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endometrium is receptive to embryo implantation only for a short period in each reproductive cycle: development of receptivity requires alterations in endometrial gene expression. Calbindin (CaBP)-d9k and CaBP-d28k are related proteins containing EF hand motifs that have a high affinity for Ca2+. We previously demonstrated that endometrial expression of CaBP-d9k mRNA is highly regulated during implantation in the mouse. This project aimed to determine the temporal and spatial expression of both CaBP proteins during early pregnancy and to establish whether they are necessary for blastocyst implantation. CaBP-d28k protein, like CaBP-d9k, was up-regulated in the endometrial epithelium just before implantation but disappeared at implantation sites after attachment. By the judicious intrauterine injection of morpholino oligonucleotides (MO) against CaBP-d9k into WT and CaBP-d28k null mice just before implantation, we selectively eliminated one or both CaBPs from the uterine epithelium. Implantation was blocked only when both CaBP-d9k and CaBP-d28k were absent: treated WT mice and untreated CaBP-d28k null mice were fertile. Furthermore, the effect on implantation was highly dependent on the timing of injection of MO. This report examining the function of implantation-related genes in the uterus using MO demonstrates that this technique is a highly effective means to specifically target uterine proteins in vivo. This study provides evidence for an absolute requirement for CaBPs during the early phase of embryo implantation, and thus that regulation of Ca2+ availability in the uterine environment of the implanting embryo is critical for successful implantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.