ArticleGut2004
P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori.
Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Deregulation of the cyclin-dependent kinase inhibitor p27 as a putative candidate for transformation inAIMS microbiology · 2023Article
- Prognostic Significance of p27 and Survivin in H. pylori Gastritis and Gastric Cancer.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- From microbiota toward gastro-enteropancreatic neuroendocrine neoplasms: Are we on the highway to hell?Reviews in endocrine & metabolic disorders · 2021Review
- Biological roles of the B cell receptor-associated protein 31: Functional Implication in Cancer.Molecular biology reports · 2021Review
- The Clinical Evidence LinkingCellular and molecular gastroenterology and hepatology · 2017Review
- Catfish rhamnose-binding lectin induces GGlycoconjugate journal · 2017Article
- KCTD5 and Ubiquitin Proteasome Signaling Are Required forFrontiers in cellular and infection microbiology · 2017Article
- Article
- Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter.Cancer letters · 2012Article
- Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer.Oncogene · 2012Article
- SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis.British journal of cancer · 2008Article
- Involvement of mast cells in gastritis caused by Helicobacter pylori: a potential role in epithelial cell apoptosis.Journal of clinical pathology · 2007Article
- Adenovirus expressing p27kip1 suppresses growth of established esophageal carcinoma xenografts.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHelicobacter pylori infection increases the risk of gastric cancer but the molecular mechanisms responsible are not well understood. Gastric cells chronically exposed to H pylori in vitro develop resistance to apoptosis associated with low levels of p27, a cyclin dependent kinase inhibitor and haplo insufficient tumour suppressor gene that is downregulated in gastric cancer.
aimTo determine whether the low level of p27 protein is responsible for the resistance to apoptosis of gastric cancer cells.
methodsThe effects of increasing the expression of p27 protein were examined by transiently and stably transfecting a plasmid encoding full length p27 mRNA into apoptosis resistant gastric cancer cell lines with low p27 expression that were derived from AGS gastric cancer cells by chronic H pylori coculture followed by dilutional cloning.
resultsLow p27 expression in the apoptosis resistant derivative cell lines was associated with an approximate 30% decrease in p27 mRNA and an 80% decrease in p27 protein that was not due to increased proteasome dependent degradation of p27 protein. Transient or stable transfection with p27 constructs partially restored the sensitivity of the apoptosis resistant cells to 5-fluorouracil and H pylori induced apoptosis without altering spontaneous apoptotic cell death.
conclusionsThese results demonstrate that p27 positively regulates, at least in part, the apoptotic response of gastric epithelial cells to H pylori. Low gastric p27 may promote gastric carcinogenesis associated with H pylori infection by inhibiting apoptotic pathways.
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Registered trials
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