ArticleClinical and diagnostic laboratory immunology2004
Effects of feeding a probiotic preparation (SIM) containing inulin on the severity of colitis and on the composition of the intestinal microflora in HLA-B27 transgenic rats.
Article in Clinical and diagnostic laboratory immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Changes in HLA-B27 Transgenic Rat Fecal Microbiota Following Tofacitinib Treatment and Ileocecal Resection Surgery: Implications for Crohn's Disease Management.International journal of molecular sciences · 2024Article
- Therapy Used to Promote Disease Remission Targeting Gut Dysbiosis, in UC Patients with Active Disease.Journal of clinical medicine · 2022Review
- Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch's postulates.Frontiers in medicine · 2022Review
- Spondyloarthritis: How far are we from precision medicine?Frontiers in medicine · 2022Review
- Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy.Frontiers in immunology · 2020Review
- Review
- Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome.Immunology · 2018Review
- Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation.Scientific reports · 2018Article
- Extraintestinal pathogenic Escherichia coli are associated with intestinal inflammation in patients with ulcerative colitis.Scientific reports · 2016Article
- Gut inflammation and microbiome in spondyloarthritis.Rheumatology international · 2016Review
- Combinatorial effects of diet and genetics on inflammatory bowel disease pathogenesis.Inflammatory bowel diseases · 2015Review
- In vivo selection to identify bacterial strains with enhanced ecological performance in synbiotic applications.Applied and environmental microbiology · 2015Article
- Part 2: Treatments for Chronic Gastrointestinal Disease and Gut Dysbiosis.Integrative medicine (Encinitas, Calif.) · 2015Review
- Intestinal microbiota: The explosive mixture at the origin of inflammatory bowel disease?World journal of gastrointestinal pathophysiology · 2014Review
- Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity.Digestive diseases and sciences · 2013Review
- The interplay between fiber and the intestinal microbiome in the inflammatory response.Advances in nutrition (Bethesda, Md.) · 2013Review
- Prebiotics in chronic intestinal inflammation.Inflammatory bowel diseases · 2009Review
- Article
- Probiotics and prebiotics in chronic inflammatory bowel diseases.World journal of gastroenterology · 2006Review
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An overly aggressive immune response to the intestinal microflora in a genetically susceptible host background has been implicated in the pathogenesis of inflammatory bowel diseases. We measured the impact of a probiotic preparation (SIM) containing inulin on the severity of colitis and on intestinal microflora profiles of HLA-B27-beta(2)-microglobulin transgenic (TG) rats. SIM is a mixture of lactobacilli, bifidobacteria, and inulin. Two-month-old TG rats received either SIM or water. Control TG rats received metronidazole, alone or in combination with SIM, for 8 weeks. Nontransgenic rats received SIM or water. The cecal content was removed for analysis of the intestinal microflora by PCR combined with denaturing gradient gel electrophoresis. The colon was scored for histological evidence of inflammation, colonic myeloperoxidase activity and interleukin-1beta RNA levels were measured photometrically or by real-time quantitative PCR. At 4 months, the colonic inflammation of TG rats treated with SIM was histologically diminished compared to that in untreated TG rats (2.2 +/- 0.2 versus 2.9 +/- 0.1; P </= 0.03). The administration of SIM altered the microflora profiles of TG rats by increasing the diversity and stimulating specifically the growth of Bifidobacterium animalis. The probiotic bacteria added to SIM were below the detection level in cecal stool samples at the end of the study period. The administration of SIM resulted in a measurable impact on the cecal microflora profiles of TG rats with attenuation of colitis. The lack of detection of any added probiotic bacteria in the cecal content suggests that prebiotic inulin is the major effective compound.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.