ArticleProceedings of the National Academy of Sciences of the United States of America2004
The effect of interspecific oocytes on demethylation of sperm DNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 118 citations in OpenAlex.
- PRAMEY enhances sperm-egg binding and modulates epigenetic dynamics in bovine embryogenesis.Cell and tissue research · 2025Article
- Pathways of DNA Demethylation.Advances in experimental medicine and biology · 2022Article
- Double sperm cloning (DSC) is a promising strategy in mammalian genetic engineering and stem cell research.Stem cell research & therapy · 2020Review
- Effects of cyclic adenosine monophosphate modulators on maturation and quality of vitrified-warmed germinal vesicle stage mouse oocytes.Reproductive biology and endocrinology : RB&E · 2020Article
- The model of "genetic compartments": a new insight into reproductive genetics.Journal of assisted reproduction and genetics · 2019Review
- Analysis of mRNA abundance for histone variants, histone- and DNA-modifiers in bovine in vivo and in vitro oocytes and embryos.Scientific reports · 2019Article
- Absence of nucleolus formation in raccoon dog-porcine interspecies somatic cell nuclear transfer embryos results in embryonic developmental failure.The Journal of reproduction and development · 2016Article
- Plasma membrane and acrosome loss before ICSI is required for sheep embryonic development.Journal of assisted reproduction and genetics · 2016Article
- Epigenetics and inheritance of phenotype variation in livestock.Epigenetics & chromatin · 2016Review
- Article
- Cross-species cloning: influence of cytoplasmic factors on development.The Journal of physiology · 2014Review
- Dynamic changes in DNA modification states during late gestation male germ line development in the rat.Epigenetics & chromatin · 2014Article
- Interspecies somatic cell nuclear transfer: advancements and problems.Cellular reprogramming · 2013Review
- DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases.The Journal of biological chemistry · 2013Article
- 5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote.PloS one · 2013Article
- Relationship between LTR methylation and gag expression of HIV-1 in human spermatozoa and sperm-derived embryos.PloS one · 2013Article
- Reprogramming and development in nuclear transfer embryos and in interspecific systems.Current opinion in genetics & development · 2012Review
- Amphibian interorder nuclear transfer embryos reveal conserved embryonic gene transcription, but deficient DNA replication or chromosome segregation.The International journal of developmental biology · 2012Article
- Article
- Efficient production and cellular characterization of sheep androgenetic embryos.Cellular reprogramming · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to mice, in sheep no genome-wide demethylation of the paternal genome occurs within the first postfertilization cell cycle. This difference could be due either to an absence of a sheep demethylase activity that is present in mouse ooplasm or to an increased protection of methylated cytosine residues in sheep sperm. Here, we use interspecies intracytoplasmic sperm injection to demonstrate that sheep sperm DNA can be demethylated in mouse oocytes. Surprisingly, mouse sperm can also be demethylated to a limited extent in sheep oocytes. Our results suggest that the murine demethylation process is facilitated either by a sperm-derived factor or by male pronuclear chromatin composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.