ArticleWorld journal of gastroenterology2004
Effect of c-myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinoma patients undergoing tumor resection.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Radiomics predicting immunohistochemical markers in primary hepatic carcinoma: Current status and challenges.Heliyon · 2024Review
- The potential chemotherapeutic effect of β-ionone and/or sorafenib against hepatocellular carcinoma via its antioxidant effect, PPAR-γ, FOXO-1, Ki-67, Bax, and Bcl-2 signaling pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- c-MYC expression in T (III/IV) stage oral squamous cell carcinoma (OSCC) patients.Cancer management and research · 2019Article
- Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection.BMC cancer · 2018Article
- Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice.The American journal of pathology · 2018Article
- Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma.International journal of biological sciences · 2017Article
- mTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma.British journal of cancer · 2015Article
- Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma.United European gastroenterology journal · 2013Article
- Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA.PloS one · 2012Article
- HCC and angiogenesis: possible targets and future directions.Nature reviews. Clinical oncology · 2011Review
- The FUSE binding protein is a cellular factor required for efficient replication of hepatitis C virus.Journal of virology · 2008Article
- Anti-angiogenic strategies in gastrointestinal malignancies.Current treatment options in oncology · 2005Review
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Authors and funding
5 authors.
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Abstract
aimTo explore the effect of c-myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinoma (HCC) patients undergoing tumor resection.
methodsPrimary HCC patients underwent tumor resection were retrospectively analysed. The maximum size of the tumor was less than 5 cm, there was only one nodule in each patient. No chemoembolization was performed before resection. They were followed up after resection, and the time of recurrence was recorded. They were divided into 2 groups: group A (15 cases): tumor recurrence within 1 year after tumor resection, and group B (15 cases): with or without tumor recurrence 2 years after tumor resection. Pathological slices were made with tumor wax-sample. Immunohistochemistry staining was performed with c-myc, Ki-67, MMP-2 and VEGF monoclonal antibodies. Staining intensity was quantitatively analysed with a pathological diagram-writing analyzing system. The expressing intensity differences of stained molecules in cancer tissue and para-cancer were analysed.
resultsc-myc, Ki-67, MMP-2 and VEGF expressing intensities in cancer tissue in group A were higher than those in group B (P values were 0.010, 0.030, 0.022 and 0.004, respectively), but they were not significantly different in para-cancer tissue in groups A and B (P values were 0.334, 0.343, 0.334 and 0.334, respectively).
conclusionThe expression of c-myc, Ki-67, MMP-2 and VEGF in cancer tissue is related to the recurrence of HCC after tumor resection.
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