ArticleWorld journal of gastroenterology2004
mRNA expression profiling reveals a role of Helicobacter pylori vacuolating toxin in escaping host defense.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Review
- Helicobacter pylori sabA gene is associated with iron deficiency anemia in childhood and adolescence.PloS one · 2017Article
- Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.Carcinogenesis · 2015Review
- Article
- NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection.World journal of gastroenterology · 2005Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the immune response of host to Helicobacter pylori VacA.
methodsThe monocyte/macrophage-like U937 cells were infected with Helicobacter pylori vacA-positive strain NCTC 11638 or isogenic vacA-negative mutant. Differentially expressed genes were identified at 2, 6, 10, and 24 h post-infection by cDNA microarray. Differential expressions of some genes were confirmed by Northern blot.
resultsMore than 100 genes altered their mRNA expression at different time points respectively, many of which were identified to be related to immune evasion.
conclusionVacA is a crucial element for H pylori to escape from host immune defense by means of differentially regulating the expression of some related genes. These genes, previously known or unknown to be involved in the mechanism of immune evasion, deserve further investigation to unearth much more information complicated in the immune response.
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