ArticleWorld journal of gastroenterology2004
Loss of heterozygosity on chromosome 1 in sporadic colorectal carcinoma.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells.Cell communication and signaling : CCS · 2023Article
- Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population.BMC medical genomics · 2019Article
- Somatic mosaicisms of chromosome 1 at two different stages of ontogenetic development detected by Rh blood group discrepancies.Haematologica · 2019Article
- Downregulation of nuclear and cytoplasmic Chibby is associated with advanced cervical cancer.Oncology letters · 2017Article
- The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.Gene expression patterns : GEP · 2013Article
- DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness.Journal of gastroenterology · 2011Article
- Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.Clinical and experimental gastroenterology · 2011Article
- Epigenetic inactivation of the NORE1 gene correlates with malignant progression of colorectal tumors.BMC cancer · 2010Article
- Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins.Nature reviews. Cancer · 2010Review
- Loss of heterozygosity at 1p, 7q, 17p, and 22q in meningiomas.Journal of Korean Neurosurgical Society · 2010Article
- The quest for the 1p36 tumor suppressor.Cancer research · 2008Review
- Refined mapping of loss of heterozygosity on 1q31.1-32.1 in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines.World journal of gastroenterology · 2006Article
- The impact of genomic alterations on the transcriptome: a prostate cancer cell line case study.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimLoss of heterozygosity (LOH) on tumor suppressor genes is believed to play a key role in carcinogenesis of colorectal cancer. When it occurs at a tumor suppressor gene locus with abnormal allele, neoplastic transformation happens. In this study, we analyzed the LOH at 21 loci on chromosome 1 in sporadic colorectal cancer to identify additional loci involved in colorectal tumorigenesis.
methodsTwenty-one polymorphic micro-satellite DNA markers were analyzed with PCR both in 83 cases of colorectal cancer and in normal tissues. PCR products were eletrophoresed on an ABI 377 DNA sequencer. Genescan 3.1 and Genotype 2.1 software were used for LOH scanning and analysis. chi2 test was used to compare LOH frequency with clinicopathological data. P<0.05 was considered as statistically significant.
resultsThe average LOH frequency of chromosome 1, short arm and long arm was 19.83%, 18.00% and 21.66%, respectively. The 2 highest LOH loci with a frequency of 36.54% and 32.50% were identified on D1S468 (1p36.33-p36.31) and D1S413 (1q31.3), respectively. On D1S2726 locus, LOH frequency of rectal cancer was 28.57% (6/21), which was higher than that of colon cancer (0.00%, 0/33) (P=0.002), suggesting that the mechanism of carcinogenesis was different in both groups.
conclusionPutative tumor suppressor genes on chromosome 1 may relate to sporadic colorectal carcinomas. Tumor-suppressor-genes might locate on 1p36.33-36.31 and/or 1q31.3.
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