ArticleJournal of genetics2003
Latitudinal clines in Drosophila melanogaster: body size, allozyme frequencies, inversion frequencies, and the insulin-signalling pathway.
Article in Journal of genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Article
- Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.PLoS genetics · 2026Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.bioRxiv : the preprint server for biology · 2025Article
- Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations ofEvolution letters · 2025Article
- Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource.Molecular biology and evolution · 2025Article
- Heat tolerance inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators.Scientific reports · 2023Article
- Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body.PLoS genetics · 2023Article
- Systemic orchestration of cell size throughout the body: influence of sex and rapamycin exposure inBiology letters · 2023Article
- Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource.Molecular biology and evolution · 2021Article
- Mother's curse is pervasive across a large mitonuclearEvolution letters · 2021Article
- Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.Molecular ecology · 2021Article
- Coevolution of body size and metabolic rate in vertebrates: a life-history perspective.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses.Molecular biology and evolution · 2020Article
- Size as a Proxy for Survival in Aedes aegypti (Diptera: Culicidae) Mosquitoes.Journal of medical entomology · 2020Article
- Assessing connectivity despite high diversity in island populations of a malaria mosquito.Evolutionary applications · 2020Article
- Larval mannitol diets increase mortality, prolong development and decrease adult body sizes in fruit flies (Biology open · 2020Article
- The Cyclically SeasonalFrontiers in genetics · 2020Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
1 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Many latitudinal clines exist in Drosophila melanogaster: in adult body size, in allele frequency at allozyme loci, and in frequencies of common cosmopolitan inversions. The question is raised whether these latitudinal clines are causally related. This review aims to connect data from two very different fields of study, evolutionary biology and cell biology, in explaining such natural genetic variation in D. melanogaster body size and development time. It is argued that adult body size clines, inversion frequency clines, and clines in allele frequency at loci involved in glycolysis and glycogen storage are part of the same adaptive strategy. Selection pressure is expected to differ at opposite ends of the clines. At high latitudes, selection on D. melanogaster would favour high larval growth rate at low temperatures, and resource storage in adults to survive winter. At low latitudes selection would favour lower larval critical size to survive crowding, and increased male activity leading to high male reproductive success. Studies of the insulin-signalling pathway in D. melanogaster point to the involvement of this pathway in metabolism and adult body size. The genes involved in the insulin-signalling pathway are associated with common cosmopolitan inversions that show latitudinal clines. Each chromosome region connected with a large common cosmopolitan inversion possesses a gene of the insulin transmembrane complex, a gene of the intermediate pathway and a gene of the TOR branch. The hypothesis is presented that temperate D. melanogaster populations have a higher frequency of a 'thrifty' genotype corresponding to high insulin level or high signal level, while tropical populations possess a more 'spendthrift' genotype corresponding to low insulin or low signal level.
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