ArticleMolecular biology of the cell2004
Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- CHC22 clathrin recruitment to the early secretory pathway requires two-site interaction with SNX5 and p115.The EMBO journal · 2024Article
- Clathrin Light Chains: Not to Be Taken so Lightly.Frontiers in cell and developmental biology · 2021Review
- In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?Journal of neurodevelopmental disorders · 2019Review
- Article
- Taming the Triskelion: Bacterial Manipulation of Clathrin.Microbiology and molecular biology reviews : MMBR · 2019Review
- Article
- A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development.Brain : a journal of neurology · 2015Article
- Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.Cold Spring Harbor perspectives in biology · 2014Review
- Isoform 5 of PIPKIγ regulates the endosomal trafficking and degradation of E-cadherin.Journal of cell science · 2014Article
- Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization.The Journal of cell biology · 2014Article
- SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.Journal of cell science · 2013Article
- Clathrin is not required for SNX-BAR-retromer-mediated carrier formation.Journal of cell science · 2013Article
- The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.PloS one · 2013Article
- Phosphoinositides in the mammalian endo-lysosomal network.Sub-cellular biochemistry · 2012Review
- Physiology and pathology of endosome-to-Golgi retrograde sorting.Traffic (Copenhagen, Denmark) · 2011Review
- The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.The Journal of cell biology · 2010Article
- A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia.Eukaryotic cell · 2009Article
- The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).The Journal of biological chemistry · 2009Article
- Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.Journal of cell science · 2009Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The muscle isoform of clathrin heavy chain, CHC22, has 85% sequence identity to the ubiquitously expressed CHC17, yet its expression pattern and function appear to be distinct from those of well-characterized clathrin-coated vesicles. In mature muscle CHC22 is preferentially concentrated at neuromuscular and myotendinous junctions, suggesting a role at sarcolemmal contacts with extracellular matrix. During myoblast differentiation, CHC22 expression is increased, initially localized with desmin and nestin and then preferentially segregated to the poles of fused myoblasts. CHC22 expression is also increased in regenerating muscle fibers with the same time course as embryonic myosin, indicating a role in muscle repair. CHC22 binds to sorting nexin 5 through a coiled-coil domain present in both partners, which is absent in CHC17 and coincides with the region on CHC17 that binds the regulatory light-chain subunit. These differential binding data suggest a mechanism for the distinct functions of CHC22 relative to CHC17 in membrane traffic during muscle development, repair, and at neuromuscular and myotendinous junctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.