ArticleNucleic acids research2004
Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mini-Hairpin DNA: Extraordinarily Stable Structure and Its Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- A novel hypervariable variable number tandem repeat in the dopamine transporter gene (Life science alliance · 2023Article
- InterMetalDB: A Database and Browser of Intermolecular Metal Binding Sites in Macromolecules with Structural Information.Journal of proteome research · 2021Article
- A metallo-DNA nanowire with uninterrupted one-dimensional silver array.Nature chemistry · 2017Article
- Guanine base stacking in G-quadruplex nucleic acids.Nucleic acids research · 2013Article
- Direct experimental evidence for quadruplex-quadruplex interaction within the human ILPR.Nucleic acids research · 2009Article
- DNA conformations and their sequence preferences.Nucleic acids research · 2008Article
- DNA architecture: from G to Z.Current opinion in structural biology · 2006Review
- Base-tetrad swapping results in dimerization of RNA quadruplexes: implications for formation of the i-motif RNA octaplex.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
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Authors and funding
5 authors.
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Abstract
Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats.
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