ArticleMicrobiology (Reading, England)2004
Genome structure in the vole bacillus, Mycobacterium microti, a member of the Mycobacterium tuberculosis complex with a low virulence for humans.
Article in Microbiology (Reading, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 53 citations in OpenAlex.
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- Genome-wide transcription analyses in Mycobacterium tuberculosis treated with lupulone.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- A simple and efficient multiplex PCR assay for the identification of Mycobacterium genus and Mycobacterium tuberculosis complex to the species level.Yonsei medical journal · 2013Article
- Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis.Journal of bacteriology · 2012Article
- A modified visual loop-mediated isothermal amplification method for diagnosis and differentiation of main pathogens from Mycobacterium tuberculosis complex.World journal of microbiology & biotechnology · 2012Article
- Mycobacterium microti--pulmonary tuberculosis in an immunocompetent patient.Wiener klinische Wochenschrift · 2009Article
- High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography.PLoS biology · 2008Article
- Species of environmental mycobacteria differ in their abilities to grow in human, mouse, and carp macrophages and with regard to the presence of mycobacterial virulence genes, as observed by DNA microarray hybridization.Applied and environmental microbiology · 2008Article
- Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans.BMC evolutionary biology · 2007Article
- Genome analysis shows a common evolutionary origin for the dominant strains of Mycobacterium tuberculosis in a UK South Asian community.Tuberculosis (Edinburgh, Scotland) · 2007Article
- Novel genetic polymorphisms that further delineate the phylogeny of the Mycobacterium tuberculosis complex.Journal of bacteriology · 2006Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Mycobacterium microti, a member of the Mycobacterium tuberculosis complex, is phylogenetically closely related to M. tuberculosis, differing in a few biochemical properties. However, these species have different levels of virulence in different hosts; most notably M. microti shows lower virulence for humans than M. tuberculosis. This report presents genomic comparisons using DNA microarray analysis for an extensive study of the diversity of M. microti strains. Compared to M. tuberculosis H37Rv, 13 deletions were identified in 12 strains of M. microti, including the regions RD1 to RD10, which are also missing in Mycobacterium bovis BCG. In addition, four new deleted regions, named MiD1, RD1beta, MiD2 and MiD3, were identified. DNA sequencing was used to define the extent of most of the deletions in one strain. Although RD1 of M. bovis BCG and M. microti is thought to be crucial for attenuation, in this study, three of the four M. microti strains that were isolated from immunocompetent patients had the RD1 deletion. In fact, only the RD3 deletion was present in all of the strains examined, although deletions RD7, RD8 and MiD1 were found in almost all the M. microti strains. These deletions might therefore have some relation to the different host range of M. microti. It was also noticeable that of the 12 strains studied, only three were identical; these strains were all isolated from immunocompetent humans, suggesting that they could have arisen from a single source. Thus, this study shows that it is difficult to ascribe virulence to any particular pattern of deletion in M. microti.
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