Evidence map›Paper›PMID 15130500›Full record

ReviewSeminars in immunology2004

Anatomical features of anti-viral immunity in the respiratory tract.

David L Woodland, Troy D Randall

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Towards new TB vaccines.Seminars in immunopathology · 2020
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Tertiary lymphoid structures target the antitumor immune response to lung cancer.American journal of respiratory and critical care medicine · 2014
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Ectopic lymphoid tissues and local immunity.Seminars in immunology · 2008
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David L WoodlandTrudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA.
Troy D Randall
Trudeau Institute · US

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LEVY, DAVID E · 2003 to 2014
$100.8M
T cell responses of nasal mucosa and lymphoid tissuesP01HL063925 · NHLBI · TRUDEAU INSTITUTE, INC. · PI LUND, FRANCES E. · 2001 to 2005
$8.9M
Unique Aspects of Respiratory ImmunityR01HL069409 · NHLBI · UNIVERSITY OF ROCHESTER · PI RANDALL, TROY D · 2001 to 2015
$5.3M
CD4+T cell immunity to respiratory virus infectionsR01HL069502 · NHLBI · TRUDEAU INSTITUTE, INC. · PI WOODLAND, DAVID L · 2001 to 2004
$1.6M
Regulation of CD8+ T cell responses to influenza virusR01AI055500 · NIAID · TRUDEAU INSTITUTE, INC. · PI WOODLAND, DAVID L · 2003 to 2007
$1.5M
NHLBI NIH HHS HL-63925NHLBI NIH HHS HL-69409NHLBI NIH HHS HL-69502NHLBI NIH HHS P01 HL063925NHLBI NIH HHS R01 HL069409NHLBI NIH HHS R01 HL069502NIAID NIH HHS AI-055500NIAID NIH HHS R01 AI055500NIAID NIH HHS U54 AI057158NIAID NIH HHS U54AI057158
6 · The paper itself

Abstract

The mucosal surfaces of the lungs are a major portal of entry for virus infections and there are urgent needs for new vaccines that promote effective pulmonary immunity. However, we have only a rudimentary understanding of the requirements for effective cellular immunity in the respiratory tract. Recent studies have revealed that specialized cellular immune responses and lymphoid tissues are involved in the protection of distinct anatomical microenvironments of the respiratory tract, such as the large airways of the nose and the alveolar airspaces. This review discusses some of the anatomical features of anti-viral immunity in the respiratory tract including the role of local lymphoid tissues and the relationship between effector and memory T cells in the airways, the lung parenchyma, and lymphoid organs.

Indexed as

AnimalsHumansImmunologic MemoryLymph NodesRespiratory SystemRespiratory Tract InfectionsT-LymphocytesVirus DiseasesViruses

Identifiers

PMID15130500
PMCPMC7128764
OpenAlexW2039008677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.