Evidence map›Paper›PMID 15129710›Full record

GuidelineEuropean journal of nuclear medicine and molecular imaging2004

Myocardial perfusion scintigraphy: the evidence.

S R Underwood, C Anagnostopoulos, M Cerqueira, P J Ell, E J Flint, M Harbinson, A D Kelion, A Al-Mohammad, E M Prvulovich, L J Shaw and 6 more

Open access · bronzeAbstract readConsensus StatementGuidelinePractice Guideline
In one paragraph

Guideline in European journal of nuclear medicine and molecular imaging, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 6 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 6 syntheses or guidelines pooled it, 476 citations in OpenAlex.

  1. Systematic review and meta‑analysis of factors predicting postoperative lung function after lung cancer resection.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024
    Pooled it
  2. Advances in Myocardial Perfusion MR Imaging: Physiological Implications, the Importance of Quantitative Analysis, and Impact on Patient Care in Coronary Artery Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Pooled it
  3. Pooled it
  4. Guideline
  5. EANM/ESC guidelines for radionuclide imaging of cardiac function.European journal of nuclear medicine and molecular imaging · 2008
    Guideline
  6. Cost-effectiveness of myocardial perfusion imaging: a summary of the currently available literature.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    Pooled it
  7. Trial
  8. Trial
  9. Development and validation of a patient-tailored dose regime in myocardial perfusion imaging using conventional SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Trial
  10. Trial
  11. Development and validation of a patient-tailored dose regime in myocardial perfusion imaging using CZT-SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Trial
  12. Validation of an automated method to quantify stress-induced ischemia and infarction in rest-stress myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Influence of 99mTc-tetrofosmin SPECT myocardial perfusion imaging on the prediction of future adverse cardiac events.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
    Trial
  19. Article
  20. Association of total Q/R ratio with myocardial scar in patients with chronic total occlusion.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026
    Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 2 countries.

S R UnderwoodImperial College London, Royal Brompton Hospital, London, UK. r.underwood@imperial.ac.uk
C Anagnostopoulos
M Cerqueira
P J Ell
E J Flint
M Harbinson
A D Kelion
A Al-Mohammad
E M Prvulovich
L J Shaw
A C Tweddel
British Cardiac Society
British Nuclear Cardiology Society
British Nuclear Medicine Society
Royal College of Physicians of London
Royal College of Radiologists
Royal Brompton Hospital · GBAntrim Area Hospital · GBCastle Hill Hospital · GBGeorgetown University Medical Center · USGeorgia Institute of Technology · USHarefield Hospital · GBNorthern General Hospital · GBNorth Middlesex Hospital · GBUniversity College London · GBWordsley Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review summarises the evidence for the role of myocardial perfusion scintigraphy (MPS) in patients with known or suspected coronary artery disease. It is the product of a consensus conference organised by the British Cardiac Society, the British Nuclear Cardiology Society and the British Nuclear Medicine Society and is endorsed by the Royal College of Physicians of London and the Royal College of Radiologists. It was used to inform the UK National Institute of Clinical Excellence in their appraisal of MPS in patients with chest pain and myocardial infarction. MPS is a well-established, non-invasive imaging technique with a large body of evidence to support its effectiveness in the diagnosis and management of angina and myocardial infarction. It is more accurate than the exercise ECG in detecting myocardial ischaemia and it is the single most powerful technique for predicting future coronary events. The high diagnostic accuracy of MPS allows reliable risk stratification and guides the selection of patients for further interventions, such as revascularisation. This in turn allows more appropriate utilisation of resources, with the potential for both improved clinical outcomes and greater cost-effectiveness. Evidence from modelling and observational studies supports the enhanced cost-effectiveness associated with MPS use. In patients presenting with stable or acute chest pain, strategies of investigation involving MPS are more cost-effective than those not using the technique. MPS also has particular advantages over alternative techniques in the management of a number of patient subgroups, including women, the elderly and those with diabetes, and its use will have a favourable impact on cost-effectiveness in these groups. MPS is already an integral part of many clinical guidelines for the investigation and management of angina and myocardial infarction. However, the technique is underutilised in the UK, as judged by the inappropriately long waiting times and by comparison with the numbers of revascularisations and coronary angiograms performed. Furthermore, MPS activity levels in this country fall far short of those in comparable European countries, with about half as many scans being undertaken per year. Currently, the number of MPS studies performed annually in the UK is 1,200/million population/year. We estimate the real need to be 4,000/million/year. The current average waiting time is 20 weeks and we recommend that clinically appropriate upper limits of waiting time are 6 weeks for routine studies and 1 week for urgent studies.

Indexed as

CardiologyCoronary Artery DiseaseCoronary VesselsEvidence-Based MedicineFemaleHeartHumansMaleNuclear MedicinePatient Care ManagementPractice Patterns, Physicians'PrognosisReproducibility of ResultsSensitivity and SpecificitySocieties, MedicalTomography, Emission-Computed, Single-Photon

Identifiers

PMID15129710
PMCPMC2562441
OpenAlexW2402495445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.