ArticleGenes and immunity2004
Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Loss of MafA and MafB expression promotes islet inflammation.Scientific reports · 2019Article
- Single nucleotide polymorphism of Methyl-CpG-binding protein 2 gene associates with juvenile idiopathic arthritis.Clinical rheumatology · 2018Article
- Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.Hypertension (Dallas, Tex. : 1979) · 2012Article
- The immunogenetic architecture of autoimmune disease.Cold Spring Harbor perspectives in biology · 2012Review
- A comprehensive review of the genetics of juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2008Article
- Unravelling the association of partial T-cell immunodeficiency and immune dysregulation.Nature reviews. Immunology · 2008Review
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-cell-specific adapter protein (TSAd) involved in the negative control of T-cell activation is encoded by the SH2D2A gene. Our recent studies indicate that homozygosity for short (ie GA(13) and GA(16)) alleles of the SH2D2A gene promoter is associated with development of multiple sclerosis. To study whether the same SH2D2A promoter polymorphism also contributes to the genetic susceptibility to develop juvenile rheumatoid arthritis (JRA), we examined 210 JRA patients and 558 healthy unrelated controls from Norway. The frequency of the short allele GA(13) was increased among the JRA patients compared to control (0.098 vs 0.05; P(n=8)=0.042). There was a significant increased frequency of HLA-DRB1(*)08-positive patients carrying two copies of 'short' alleles GA(13) and/or GA(16) compared to healthy controls (16% vs 6%; P(n=4)=0.016). Our data indicate that the 'short' alleles of the SH2D2A promoter could contribute to the genetic susceptibility to JRA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.