ArticleApplied and environmental microbiology2004
Novel polyketide synthase from Nectria haematococca.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Inventory of the Secondary Metabolite Biosynthetic Potential of Members within the Terminal Clade of theJournal of fungi (Basel, Switzerland) · 2023Article
- Advances in linking polyketides and non-ribosomal peptides to their biosynthetic gene clusters in Fusarium.Current genetics · 2019Review
- A polyketide synthase gene cluster associated with the sexual reproductive cycle of the banana pathogen, Pseudocercospora fijiensis.PloS one · 2019Article
- Comparative Genomics and Transcriptomics During Sexual Development Gives Insight Into the Life History of the Cosmopolitan FungusFrontiers in microbiology · 2019Article
- Identification of an intermediate for 1,8-dihydroxynaphthalene-melanin synthesis in a race-2 isolate ofHeliyon · 2018Article
- Phytotoxic Activity of Metabolites Isolated fromMolecules (Basel, Switzerland) · 2018Article
- Identification of the non-ribosomal peptide synthetase responsible for biosynthesis of the potential anti-cancer drug sansalvamide in Fusarium solani.Current genetics · 2016Article
- Black perithecial pigmentation in Fusarium species is due to the accumulation of 5-deoxybostrycoidin-based melanin.Scientific reports · 2016Article
- The Fusarium solani species complex: ubiquitous pathogens of agricultural importance.Molecular plant pathology · 2016Review
- Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1.Scientific reports · 2015Article
- A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogenMycology · 2014Article
- The polyketide synthase gene pks4 of Trichoderma reesei provides pigmentation and stress resistance.Eukaryotic cell · 2013Article
- Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia.Applied and environmental microbiology · 2012Article
- Review
- A novel polyketide biosynthesis gene cluster is involved in fruiting body morphogenesis in the filamentous fungi Sordaria macrospora and Neurospora crassa.Current genetics · 2009Article
- Towards prediction of metabolic products of polyketide synthases: an in silico analysis.PLoS computational biology · 2009Article
- Dothideomycete plant interactions illuminated by genome sequencing and EST analysis of the wheat pathogen Stagonospora nodorum.The Plant cell · 2007Article
- Evolution of the aflatoxin gene cluster.Mycotoxin research · 2006Article
- Putative polyketide synthase and laccase genes for biosynthesis of aurofusarin in Gibberella zeae.Applied and environmental microbiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified a polyketide synthase (PKS) gene, pksN, from a strain of Nectria haematococca by complementing a mutant unable to synthesize a red perithecial pigment. pksN encodes a 2,106-amino-acid polypeptide with conserved motifs characteristic of type I PKS enzymatic domains: beta-ketoacyl synthase, acyltransferase, duplicated acyl carrier proteins, and thioesterase. The pksN product groups with the Aspergillus nidulans WA-type PKSs involved in conidial pigmentation and melanin, bikaverin, and aflatoxin biosynthetic pathways. Inactivation of pksN did not cause any visible change in fungal growth, asexual sporulation, or ascospore formation, suggesting that it is involved in a specific developmental function. We propose that pksN encodes a novel PKS required for the perithecial red pigment biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.