ReviewEuropean journal of biochemistry2004
Prokaryotic and eukaryotic DNA helicases. Essential molecular motor proteins for cellular machinery.
Review in European journal of biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 161 citations in OpenAlex.
- Article
- A 25K Wheat SNP Array Revealed the Genetic Diversity and Population Structure of Durum Wheat (International journal of molecular sciences · 2025Article
- Role of DEAD/DEAH-box helicases in immunity, infection and cancers.Cell communication and signaling : CCS · 2025Review
- Influence of arbuscular mycorrhizal fungi on morpho-biochemical characteristics, nutrient uptake, and transcriptomic profile of3 Biotech · 2025Article
- Two novel phages infectingFrontiers in microbiology · 2025Article
- Molecular Mechanism During Mycelium Subculture Degeneration ofJournal of fungi (Basel, Switzerland) · 2024Article
- Probing the metalloproteome: an 8-mercaptoquinoline motif enriches minichromosome maintenance complex components as significant metalloprotein targets in live cells.RSC chemical biology · 2024Article
- Whole Genome Resequencing Revealed the Effect of HelicaseInternational journal of molecular sciences · 2023Article
- Pyramiding of transcription factor,Frontiers in plant science · 2023Article
- Inhibitory effects of anthracyclines on partially purified 5'-3' DNA helicase of Plasmodium falciparum.Malaria journal · 2022Article
- Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy.Frontiers in oncology · 2022Review
- History of DNA Helicases.Genes · 2020Review
- Too Much of a Good Thing: How Ectopic DNA Replication Affects Bacterial Replication Dynamics.Frontiers in microbiology · 2020Review
- Tree of motility - A proposed history of motility systems in the tree of life.Genes to cells : devoted to molecular & cellular mechanisms · 2020Review
- Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine.Nature communications · 2019Article
- Plasmodium falciparum specific helicase 2 is a dual, bipolar helicase and is crucial for parasite growth.Scientific reports · 2019Article
- Pea p68, a DEAD-box helicase, enhances salt tolerance in marker-free transgenic plants of soybean [3 Biotech · 2019Article
- Epigenetic regulation of long non-coding RNAs in gastric cancer.Oncotarget · 2018Review
- Article
- RNA helicase DHX15 acts as a tumour suppressor in glioma.British journal of cancer · 2017Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA helicases are ubiquitous molecular motor proteins which harness the chemical free energy of ATP hydrolysis to catalyze the unwinding of energetically stable duplex DNA, and thus play important roles in nearly all aspects of nucleic acid metabolism, including replication, repair, recombination, and transcription. They break the hydrogen bonds between the duplex helix and move unidirectionally along the bound strand. All helicases are also translocases and DNA-dependent ATPases. Most contain conserved helicase motifs that act as an engine to power DNA unwinding. All DNA helicases share some common properties, including nucleic acid binding, NTP binding and hydrolysis, and unwinding of duplex DNA in the 3' to 5' or 5' to 3' direction. The minichromosome maintenance (Mcm) protein complex (Mcm4/6/7) provides a DNA-unwinding function at the origin of replication in all eukaryotes and may act as a licensing factor for DNA replication. The RecQ family of helicases is highly conserved from bacteria to humans and is required for the maintenance of genome integrity. They have also been implicated in a variety of human genetic disorders. Since the discovery of the first DNA helicase in Escherichia coli in 1976, and the first eukaryotic one in the lily in 1978, a large number of these enzymes have been isolated from both prokaryotic and eukaryotic systems, and the number is still growing. In this review we cover the historical background of DNA helicases, helicase assays, biochemical properties, prokaryotic and eukaryotic DNA helicases including Mcm proteins and the RecQ family of helicases. The properties of most of the known DNA helicases from prokaryotic and eukaryotic systems, including viruses and bacteriophages, are summarized in tables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.