ArticleIntensive care medicine2004
Lipopolysaccharide-binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and C-reactive protein.
Article in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 83 citations in OpenAlex.
- Lipopolysaccharide binding protein and sCD14 are not produced as acute phase proteins in cardiac surgery.Mediators of inflammation · 2007Trial
- Interleukin-6 as a sepsis biomarker in neonatal and pediatric care: A retrospective real world cohort study.European journal of pediatrics · 2026Article
- Diagnostic Accuracy of Endotoxin and Endotoxin Binding Protein in Late-Onset Neonatal Sepsis.Indian journal of pediatrics · 2025Article
- Biomarkers Predicting Tissue Pharmacokinetics of Antimicrobials in Sepsis: A Review.Clinical pharmacokinetics · 2022Review
- Kawasaki Disease Complicated byCase reports in pediatrics · 2021Article
- The value of interleukin-6 (IL-6) within 6 hours after birth in the prompt diagnosis of early-onset neonatal sepsis.Translational pediatrics · 2020Article
- Early Inflammatory Markers for the Diagnosis of Late-Onset Sepsis in Neonates: The Nosodiag Study.Frontiers in pediatrics · 2018Article
- Diagnostics for neonatal sepsis: current approaches and future directions.Pediatric research · 2017Review
- Predictive values for procalcitonin in the diagnosis of neonatal sepsis.Electronic physician · 2015Article
- Use of early biomarkers in neonatal brain damage and sepsis: state of the art and future perspectives.BioMed research international · 2015Review
- Diagnostic accuracy of lipopolysaccharide-binding protein for predicting bacteremia/clinical sepsis in children with febrile neutropenia: comparison with interleukin-6, procalcitonin, and C-reactive protein.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Article
- Role of biomarkers in sepsis care.Shock (Augusta, Ga.) · 2013Review
- Lipopolysaccharide-binding protein: a potential marker of febrile urinary tract infection in childhood.Pediatric nephrology (Berlin, Germany) · 2013Article
- Diagnostic value of lipopolysaccharide-binding protein and procalcitonin for sepsis diagnosis in forensic pathology.International journal of legal medicine · 2013Article
- Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice.Shock (Augusta, Ga.) · 2012Article
- Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings.Journal of global health · 2011Article
- Can serum procalcitonin and C-reactive protein as nosocomial infection markers in hospitalized patients without localizing signs?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
- Article
- Lipopolysaccharide-binding protein for monitoring of postoperative sepsis: complemental to C-reactive protein or redundant?PloS one · 2011Article
- Biomarkers for late-onset neonatal sepsis: cytokines and beyond.Clinics in perinatology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate markers of infection in critically ill neonates and children, comparing lipopolysaccharide-binding protein (LBP) with procalcitonin (PCT), interleukin-6 (IL-6), and C-reactive protein (CRP). DESIGN AND
settingProspective, observational study in the level III multidisciplinary neonatal and pediatric intensive care unit. PATIENTS: Sixty patients with systemic inflammatory response syndrome (SIRS) and suspected infection classified into two groups: SIRS/sepsis ( n=33) and SIRS/no sepsis ( n=27). We included 29 neonates aged less than 48 h (neonates <48 h), 12 neonates older than 48 h (neonates >48 h), and 19 children. Median disease severity was high in neonates aged under 48 h and moderate in neonates aged over 48 h and children.
interventionsSerum LBP, PCT, IL-6, and CRP were measured on two consecutive days. Area under the receiver operating characteristic (ROC) curve (AUC), sensitivity, specificity, and predictive values were evaluated.
resultsSerum LBP was higher in patients with SIRS/sepsis than in patients with SIRS/no sepsis. AUC for LBP on the first day of suspected infection was 0.89 in the younger neonates, 0.93 in the older neonates, and 0.91 in children.
conclusionsIn critically ill neonates aged under 48 h LBP on the first day of suspected infection is a better marker of sepsis than IL-6 and PCT, and is similar to CRP. In critically ill neonates aged over 48 h and children LBP is a better marker than IL-6 and CRP, and is similar to PCT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.