ArticleJournal of bacteriology2004
ClgR, a novel regulator of clp and lon expression in Streptomyces.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Stress Response in Bifidobacteria.Microbiology and molecular biology reviews : MMBR · 2022Review
- Antibiotic Acyldepsipeptides Stimulate themBio · 2022Article
- Degradation Mechanism of AAA+ Proteases and Regulation ofBiomolecules · 2022Review
- Genome-Wide Assessment of Stress-Associated Genes in Bifidobacteria.Applied and environmental microbiology · 2022Article
- ClpP inhibitors are produced by a widespread family of bacterial gene clusters.Nature microbiology · 2022Article
- Article
- Ectopic Expression of Rv0023 Mediates Isoniazid/Ethionamide Tolerance via Altering NADH/NADFrontiers in microbiology · 2020Article
- TheFrontiers in microbiology · 2020Article
- The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an AccessoryApplied and environmental microbiology · 2019Article
- Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate.Molecular cell · 2017Article
- Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme.Trends in microbiology · 2017Review
- Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism.BMC microbiology · 2014Article
- The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress.PloS one · 2014Article
- DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks.Cold Spring Harbor perspectives in biology · 2013Review
- Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.PloS one · 2013Article
- Conservation of thiol-oxidative stress responses regulated by SigR orthologues in actinomycetes.Molecular microbiology · 2012Article
- High-throughput screening for Streptomyces antibiotic biosynthesis activators.Applied and environmental microbiology · 2012Article
- ClpR protein-like regulator specifically recognizes RecA protein-independent promoter motif and broadly regulates expression of DNA damage-inducible genes in mycobacteria.The Journal of biological chemistry · 2011Article
- Mycobacterium tuberculosis MT2816 encodes a key stress-response regulator.The Journal of infectious diseases · 2010Article
- Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis.PloS one · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clp genes encoding the Clp proteolytic complex are widespread among living organisms. Five clpP genes are present in Streptomyces. Among them, the clpP1 clpP2 operon has been shown to be involved in the Streptomyces growth cycle, as a mutation blocked differentiation at the substrate mycelium step. Four Clp ATPases have been identified in Streptomyces coelicolor (ClpX and three ClpC proteins) which are potential partners of ClpP1 ClpP2. The clpC1 gene appears to be essential, since no mutant has yet been obtained. clpP1 clpP2 and clpC1 are important for Streptomyces growth, and a study of their regulation is reported here. The clpP3 clpP4 operon, which has been studied in Streptomyces lividans, is induced in a clpP1 mutant strain, and regulation of its expression is mediated via PopR, a transcriptional regulator. We report here studies of clgR, a paralogue of popR, in S. lividans. Gel mobility shift assays and DNase I footprinting indicate that ClgR binds not only to the clpP1 and clpC1 promoters, but also to the promoter of the Lon ATP-dependent protease gene and the clgR promoter itself. ClgR recognizes the motif GTTCGC-5N-GCG. In vivo, ClgR acts as an activator of clpC1 gene and clpP1 operon expression. Similarly to PopR, ClgR degradation might be ClpP dependent and could be mediated via recognition of the two carboxy-terminal alanine residues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.