ArticleJournal of bacteriology2004
Dual control of Helicobacter pylori heat shock gene transcription by HspR and HrcA.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Methanotroph Methylotuvimicrobium alcaliphilum 20Z-3E as a fumarate producer: transcriptomic analysis and the role of malic enzyme.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress.bioRxiv : the preprint server for biology · 2025Article
- Insights into the Orchestration of Gene Transcription Regulators inInternational journal of molecular sciences · 2022Review
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- Cooperative Regulation ofMicroorganisms · 2020Article
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- Article
- The Interplay between Two Transcriptional Repressors and Chaperones OrchestratesInternational journal of molecular sciences · 2018Review
- TheFrontiers in microbiology · 2018Article
- Gene Expression Profiling of Transcription Factors ofFrontiers in microbiology · 2017Article
- A Chlamydia-specific C-terminal region of the stress response regulator HrcA modulates its repressor activity.Journal of bacteriology · 2011Article
- CbpA acts as a modulator of HspR repressor DNA binding activity in Helicobacter pylori.Journal of bacteriology · 2011Article
- Built shallow to maintain homeostasis and persistent infection: insight into the transcriptional regulatory network of the gastric human pathogen Helicobacter pylori.PLoS pathogens · 2010Review
- Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon.Genome biology · 2009Article
- Identification of Campylobacter jejuni genes involved in the response to acidic pH and stomach transit.Applied and environmental microbiology · 2008Article
- Transcriptional regulation of stress response and motility functions in Helicobacter pylori is mediated by HspR and HrcA.Journal of bacteriology · 2007Article
- Nickel represses the synthesis of the nickel permease NixA of Helicobacter pylori.Journal of bacteriology · 2006Article
- Use of genome-wide expression profiling and mutagenesis to study the intestinal lifestyle of Campylobacter jejuni.Infection and immunity · 2005Article
- The RpoH-mediated stress response in Neisseria gonorrhoeae is regulated at the level of activity.Journal of bacteriology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The HspR repressor regulates transcription of the groESL, hrcA-grpE-dnaK, and cbpA-hspR-orf operons of Helicobacter pylori. Here we show that two of the HspR-regulated operons, namely, the groESL and dnaK operons, encoding the major cellular chaperone machineries are also regulated by the H. pylori homologue of the HrcA repressor. Similarly to the hspR mutation, deletion of the hrcA gene also leads to complete derepression of the Pgro and Phrc promoters. The presence of both HspR and HrcA is therefore necessary for regulated transcription from these promoters. HrcA binds directly to Pgro and Phrc, likely contacting two inverted repeats with similarity to the CIRCE motif, which are present on both promoters. HrcA regulation is, however, shown to depend on binding of the HspR protein, since deletion of the HspR-binding site of the Pgro promoter leads to loss of heat inducibility of this promoter. In contrast, transcription from the Pcbp promoter is regulated solely by HspR. HspR is also shown to form oligomers in vivo through a stretch of hydrophobic repeats between amino acid positions 66 and 97. The implications of these findings for the elucidation of the networks regulating heat shock gene expression in H. pylori are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.