ArticleJournal of bacteriology2004
OmpR and LeuO positively regulate the Salmonella enterica serovar Typhi ompS2 porin gene.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- The LysR-Type Transcription Regulator YhjC Promotes the Systemic Infection of Salmonella Typhimurium in Mice.International journal of molecular sciences · 2023Article
- LeuO, a LysR-Type Transcriptional Regulator, Is Involved in Biofilm Formation and Virulence ofFrontiers in cellular and infection microbiology · 2021Article
- The CRISPR-Cas System Is Involved in OmpR Genetic Regulation for Outer Membrane Protein Synthesis inFrontiers in microbiology · 2021Article
- Differential functional patterns of memory CD4Vaccine · 2020Article
- Article
- The Salmonella enterica serovar Typhi LeuO global regulator forms tetramers: residues involved in oligomerization, DNA binding, and transcriptional regulation.Journal of bacteriology · 2014Article
- The Subtleties and Contrasts of the LeuO Regulator in Salmonella Typhi: Implications in the Immune Response.Frontiers in immunology · 2014Review
- Salmonella Typhi OmpS1 and OmpS2 porins are potent protective immunogens with adjuvant properties.Immunology · 2013Article
- Metabolic Regulation of a Bacterial Cell System with Emphasis on Escherichia coli Metabolism.ISRN biochemistry · 2013Review
- Transcriptional regulation of the assT-dsbL-dsbI gene cluster in Salmonella enterica serovar Typhi IMSS-1 depends on LeuO, H-NS, and specific growth conditions.Journal of bacteriology · 2012Article
- The CRISPR/Cas immune system is an operon regulated by LeuO, H-NS, and leucine-responsive regulatory protein in Salmonella enterica serovar Typhi.Journal of bacteriology · 2011Article
- A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhi.PLoS genetics · 2009Article
- Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux.Journal of bacteriology · 2009Article
- The LysR-type transcriptional regulator LeuO controls expression of several genes in Salmonella enterica serovar Typhi.Journal of bacteriology · 2008Article
- Regulation of the yjjQ-bglJ operon, encoding LuxR-type transcription factors, and the divergent yjjP gene by H-NS and LeuO.Journal of bacteriology · 2008Article
- Identification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK.Molecular microbiology · 2007Article
- Two-component signal transduction systems, environmental signals, and virulence.Microbial ecology · 2006Review
- Salmonella enterica serovar Typhimurium ompS1 and ompS2 mutants are attenuated for virulence in mice.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Salmonella enterica serovar Typhi ompS2 gene codes for a 362-amino-acid outer membrane protein that contains motifs common to the porin superfamily. It is expressed at very low levels compared to the major OmpC and OmpF porins, as observed for S. enterica serovar Typhi OmpS1, Escherichia coli OmpN, and Klebsiella pneumoniae OmpK37 quiescent porins. A region of 316 bp, between nucleotides -413 and -97 upstream of the transcriptional start point, is involved in negative regulation, as its removal resulted in a 10-fold increase in ompS2 expression in an S. enterica serovar Typhi wild-type strain. This enhancement in expression was not observed in isogenic mutant strains, which had specific deletions of the regulatory ompB (ompR envZ) operon. Furthermore, ompS2 expression was substantially reduced in the presence of the OmpR D55A mutant, altered in the major phosphorylation site. Upon random mutagenesis, a mutant where the transposon had inserted into the upstream regulatory region of the gene coding for the LeuO regulator, showed an increased level of ompS2 expression. Augmented expression of ompS2 was also obtained upon addition of cloned leuO to the wild-type strain, but not in an ompR isogenic derivative, consistent with the notion that the transposon insertion had increased the cellular levels of LeuO and with the observed dependence on OmpR. Moreover, LeuO and OmpR bound in close proximity, but independently, to the 5' upstream regulatory region. Thus, the OmpR and LeuO regulators positively regulate ompS2.
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