ArticleGenetics2004
The evolution of the Drosophila sex-determination pathway.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- The transformer gene controls sexual development in Drosophila suzukii.Insect science · 2026Article
- Autosomally-encoded segregation distortion of sex chromosomes.Proceedings. Biological sciences · 2025Article
- Evidence for a Novel X Chromosome in Termites.Genome biology and evolution · 2024Article
- Article
- Finishing the egg.Genetics · 2024Article
- Divergent evolution of genetic sex determination mechanisms along environmental gradients.Evolution letters · 2023Article
- Theme and variation in the evolution of insect sex determination.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Review
- Article
- Full Functional Sex Reversal Achieved Through Silencing ofFrontiers in endocrinology · 2021Article
- Review
- Article
- Transforming insect population control with precision guided sterile males with demonstration in flies.Nature communications · 2019Article
- Positive Selection of Squalene Synthase in Cucurbitaceae Plants.International journal of genomics · 2019Article
- Making sense of intralocus and interlocus sexual conflict.Ecology and evolution · 2018Review
- Article
- Transcriptome Differences between Alternative Sex Determining Genotypes in the House Fly, Musca domestica.Genome biology and evolution · 2015Article
- The comparative study of five sex-determining proteins across insects unveils high rates of evolution at basal components of the sex determination cascade.Development genes and evolution · 2015Article
- The evolving puzzle of autosomal versus Y-linked male determination in Musca domestica.G3 (Bethesda, Md.) · 2014Article
- Patterns and mechanisms of evolutionary transitions between genetic sex-determining systems.Cold Spring Harbor perspectives in biology · 2014Review
- Altering the sex determination pathway in Drosophila fat body modifies sex-specific stress responses.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular complexity of the Drosophila somatic sex-determination pathway poses formidable intellectual challenges for attempts to explain its evolutionary origins. Here we present a reconstruction of how this regulatory cascade might have evolved in a step-by-step fashion. We illustrate how mutations in genes, which were already part of the pathway or were recruited as new regulators of the pathway, were favored by sexual selection acting on the discriminatory sex-determining signal. This allows us to explain the major features of the pathway, including multiple promoter sites, alternative splicing patterns, autoregulation, and stop codons. Our hypothesis is built on the available data from Drosophila and other insect species, and we point out where it is amenable to further experimental and comparative tests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.