ArticleGenetics2004
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- Decoupling metabolic defense: Mutational and recombinational chaos in Sod1-deficient cells.PLoS genetics · 2026Article
- Article
- Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake.bioRxiv : the preprint server for biology · 2025Article
- Role ofInternational journal of molecular sciences · 2021Article
- The genetic basis of differential autodiploidization in evolving yeast populations.G3 (Bethesda, Md.) · 2021Article
- The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription.Journal of cell science · 2021Article
- SSD1 modifies phenotypes of Elongator mutants.Current genetics · 2020Review
- Article
- SSD1 suppresses phenotypes induced by the lack of Elongator-dependent tRNA modifications.PLoS genetics · 2019Article
- Article
- The NDR Kinase Cbk1 Downregulates the Transcriptional Repressor Nrg1 through the mRNA-Binding Protein Ssd1 in Candida albicans.Eukaryotic cell · 2015Article
- PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae.Age (Dordrecht, Netherlands) · 2015Article
- SIRT1 and other sirtuins in metabolism.Trends in endocrinology and metabolism: TEM · 2014Review
- Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.PloS one · 2014Article
- A growing role for hypertrophy in senescence.FEMS yeast research · 2013Article
- Yeast as a model to understand the interaction between genotype and the response to calorie restriction.FEBS letters · 2012Review
- Turbidostat culture of Saccharomyces cerevisiae W303-1A under selective pressure elicited by ethanol selects for mutations in SSD1 and UTH1.FEMS yeast research · 2012Article
- PAS kinase promotes cell survival and growth through activation of Rho1.Science signaling · 2012Article
- NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.PloS one · 2012Article
- Nucleocytoplasmic shuttling of Ssd1 defines the destiny of its bound mRNAs.Molecular microbiology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to attain maximal life span. Past studies of yeast aging have been performed in short-lived ssd1-d strain backgrounds. We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.