Trial reportBMJ (Clinical research ed.)2004
Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project.
Trial report in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Eradication of Helicobacter Pylori Infections and GERD: A systematic review and meta-analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Pooled it
- Helicobacter pylori eradication for the prevention of gastric neoplasia.The Cochrane database of systematic reviews · 2020Pooled it
- ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.The American journal of gastroenterology · 2017Guideline
- Helicobacter pylori eradication for the prevention of gastric neoplasia.The Cochrane database of systematic reviews · 2015Pooled it
- Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials.BMJ (Clinical research ed.) · 2014Pooled it
- Helicobacter pylori infection.BMJ clinical evidence · 2009Pooled it
- Eradication ofHealth technology assessment (Winchester, England) · 2025Trial
- Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial.BMJ (Clinical research ed.) · 2006Trial
- Does Treatment ofGastroenterology & hepatology · 2026Article
- The importance ofFrontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Causal relationship between Helicobacter pylori antibodies and gastroesophageal reflux disease (GERD): A mendelian study.PloS one · 2023Article
- Management of Helicobacter pylori infection: The Bhubaneswar Consensus Report of the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Endoscopic Reflux Esophagitis and Reflux-Related Symptoms afterJournal of clinical medicine · 2020Article
- Interactions between Helicobacter pylori and gastroesophageal reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2019Review
- Population screening and treatment of Helicobacter pylori infection.Nature reviews. Gastroenterology & hepatology · 2017Review
- Dyspepsia and Helicobacter pylori.BMJ (Clinical research ed.) · 2007Review
- Helicobacter pylori: present status and future prospects in Japan.Journal of gastroenterology · 2007Review
- Helicobacter pylori and gastro-oesophageal reflux disease: important data were not presented.BMJ (Clinical research ed.) · 2004Article
- Helicobacter pylori and gastro-oesophageal reflux disease: information underlying pathology is not given.BMJ (Clinical research ed.) · 2004Article
- Eradicating H pylori.BMJ (Clinical research ed.) · 2004Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux.
designCross sectional study, followed by a randomised placebo controlled trial.
settingSeven general practices in Bristol, England.
participants10,537 people, aged 20-59 years, with and without H pylori infection (determined by the (13)C-urea breath test).
main outcome measuresPrevalence of heartburn and gastro-oesophageal acid reflux at baseline and two years after treatment to eradicate H pylori infection.
resultsAt baseline, H pylori infection was associated with increased prevalence of heartburn (odds ratio 1.14, 95% confidence interval 1.05 to 1.23) but not reflux (1.05, 0.97 to 1.14). In participants with H pylori infection, active treatment had no effect on the overall prevalence of heartburn (0.99, 0.88 to 1.12) or reflux (1.04, 0.91 to 1.19) and did not improve pre-existing symptoms of heartburn or reflux.
conclusionsH pylori infection is associated with a slightly increased prevalence of heartburn but not reflux. Treatment to eradicate H pylori has no net benefit in patients with heartburn or gastro-oesophageal reflux.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.