ArticleThe Journal of clinical investigation2004
Lost in transdifferentiation.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
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- Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells.Stem cell research & therapy · 2021Article
- TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.Cold Spring Harbor perspectives in biology · 2017Review
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- Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.Current vascular pharmacology · 2013Article
- Smooth muscle cell plasticity: fact or fiction?Circulation research · 2013Article
- PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair.PloS one · 2013Article
- The reactive stroma microenvironment and prostate cancer progression.Endocrine-related cancer · 2012Review
- Monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- MicroRNAs in Vascular Biology.International journal of vascular medicine · 2012Article
- Vascular extracellular matrix and arterial mechanics.Physiological reviews · 2009Review
- Emerging hematological targets and therapy for cardiovascular disease: From bench to bedside.Biologics : targets & therapy · 2008Article
- Contribution of VCAF-positive cells to neovascularization and calcification in atherosclerotic plaque development.The Journal of pathology · 2007Article
- Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.The Journal of clinical investigation · 2006Article
- 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo.The Journal of clinical investigation · 2005Article
- Progenitor cells of the testosterone-producing Leydig cells revealed.The Journal of cell biology · 2004Article
- Muscle LIM protein promotes expression of the acetylcholine receptor gamma-subunit gene cooperatively with the myogenin-E12 complex.Cellular and molecular life sciences : CMLS · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What are the true origins of the smooth muscle cells (SMCs) present in the intimal lesions of transplant arteriosclerosis? A new study in the JCI shows that Sca-1(+) cells purified from the mouse aortic root can migrate through an irradiated vein graft to the neointima of the vessel and transdifferentiate to express the early SMC differentiation marker gene SM22. Do Sca-1(+) cells transdifferentiate into SMC-like cells, or is activation of SMC marker genes a consequence of fusion of these cells with preexisting SMCs, a possibility raised by results of studies of adult stem cells in animal models of liver regeneration ? Or could this be bona fide transdifferentiation that recapitulates the pathologic processes in humans?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.