ArticleProceedings of the National Academy of Sciences of the United States of America2004
Genome-wide somatic hypermutation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- A Framework for Investigating Rules of Life by Establishing Zones of Influence.Integrative and comparative biology · 2022Article
- Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis.Cancer immunology, immunotherapy : CII · 2021Article
- Directed evolution in mammalian cells.Nature methods · 2021Review
- Optimized high-fidelity 3DPCR to assess potential mitochondrial targeting by activation-induced cytidine deaminase.FEBS open bio · 2020Article
- Aptitude of Oxidative Enzymes for Treatment of Wastewater Pollutants: A Laccase Perspective.Molecules (Basel, Switzerland) · 2019Review
- Probing pathways of adaptation with continuous evolution.Current opinion in systems biology · 2019Article
- An Adaptable Platform for Directed Evolution in Human Cells.Journal of the American Chemical Society · 2018Article
- Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display.Antibodies (Basel, Switzerland) · 2018Article
- Transient AID expression for in situ mutagenesis with improved cellular fitness.Scientific reports · 2018Article
- Stochastic synchronization of neurons: the topologicalimpacts.Bioinformation · 2018Article
- A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.Frontiers in immunology · 2017Review
- Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.Journal of cancer research and clinical oncology · 2016Article
- Article
- Tuning gene expression with synthetic upstream open reading frames.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells.Nature immunology · 2013Article
- Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer.Cancer immunology, immunotherapy : CII · 2012Review
- Affinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells.Protein & cell · 2012Article
- Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.PLoS genetics · 2012Article
- LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase.PloS one · 2012Article
- Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Advances in cancer research · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially dangerous, it has been hypothesized that mutations do not occur throughout the genome but instead are actively targeted to the Ig loci. Here we challenge this longstanding and widely accepted hypothesis. We demonstrate that hypermutation requires no Ig gene sequences. Instead, activation-induced cytidine deaminase and other trans-acting hypermutation factors may function as general mutators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.