ArticleInternational journal of cancer2004
Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma.
Article in International journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies.Molecular cancer therapeutics · 2024Article
- Antitumor effect of antibiotic resistance gene-free plasmids encoding interleukin-12 in canine melanoma model.Cancer gene therapy · 2018Article
- Gamma Interferon-Regulated Chemokines in Leishmania donovani Infection in the Liver.Infection and immunity · 2017Article
- IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.Experimental parasitology · 2015Article
- Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.Infection and immunity · 2015Article
- New insights into IL-12-mediated tumor suppression.Cell death and differentiation · 2015Review
- Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells.F1000Research · 2015Review
- Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver.Infection and immunity · 2013Article
- Article
- Hypertonic Saline Attenuates the Pro-metastatic Effects of LPS by Reducing Tumor Cell Migration, Proliferation and MMP-9 Expression.World journal of oncology · 2011Article
- Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway.The Journal of biological chemistry · 2011Article
- Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma.Brain, behavior, and immunity · 2010Article
- Chronic stress and susceptibility to skin cancer.Journal of the National Cancer Institute · 2005Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that resembles human breast cancer, following the therapeutic application of recombinant IL-12, which restricted tumor growth and metastasis. IL-12 was able to curtail neovascularization in the tumor as well as enhance the number of tumor-infiltrating lymphocytes. Comprehensive examination of global gene expression revealed IL-12-induced molecular changes associated with tumor regression and reduced lung metastasis, thus providing a high-resolution snapshot of a host response against a developing malignancy and a rich source of potential targets for therapeutic intervention of breast cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.