ArticleMolecular biology of the cell2004
Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Emerging Role of Sorting Nexin 17 in Human Health and Disease.Current protein & peptide science · 2024Review
- An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis.JCI insight · 2023Article
- Sorting nexins: role in the regulation of blood pressure.The FEBS journal · 2023Review
- Sorting nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes.Haematologica · 2022Article
- Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules.Blood · 2022Article
- COMManding platelet α-granule cargo.Blood · 2022Article
- Article
- The emerging role of sorting nexins in cardiovascular diseases.Clinical science (London, England : 1979) · 2019Review
- To degrade or not to degrade: mechanisms and significance of endocytic recycling.Nature reviews. Molecular cell biology · 2018Review
- Biogenesis of endosome-derived transport carriers.Cellular and molecular life sciences : CMLS · 2015Review
- Article
- Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients.Cell & bioscience · 2013Article
- Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells.Cell regeneration (London, England) · 2013Article
- Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail.Nature cell biology · 2012Article
- Human papillomavirus L2 facilitates viral escape from late endosomes via sorting nexin 17.Traffic (Copenhagen, Denmark) · 2012Article
- SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1.Cell regeneration (London, England) · 2012Article
- Phosphoinositides in the mammalian endo-lysosomal network.Sub-cellular biochemistry · 2012Review
- Sorting Nexin 17 Interacts Directly with Kinesin Superfamily KIF1Bbeta Protein.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transient appearance of P-selectin on the surface of endothelial cells helps recruit leukocytes into sites of inflammation. The tight control of cell surface P-selectin on these cells depends on regulated exocytosis of Weibel-Palade bodies where the protein is stored and on its rapid endocytosis. After endocytosis, P-selectin is either sorted via endosomes and the Golgi apparatus for storage in Weibel-Palade bodies or targeted to lysosomes for degradation. A potential player in this complex endocytic itinerary is SNX17, a member of the sorting nexin family, which has been shown in a yeast two-hybrid assay to bind P-selectin. Here, we show that overexpression of SNX17 in mammalian cells can influence two key steps in the endocytic trafficking of P-selectin. First, it promotes the endocytosis of P-selectin from the plasma membrane. Second, it inhibits the movement of P-selectin into lysosomes, thereby reducing its degradation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.