ArticleMolecular and cellular biology2004
Groucho oligomerization is required for repression in vivo.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Systemic degradation of repressive transcription factors gates gene expression and cell fate specification.bioRxiv : the preprint server for biology · 2026Article
- Juvenile hormone-mediated chromatin remodelling by cumulative action of downstream transcription factors, Hairy and Krüppel homolog 1.Communications biology · 2026Article
- Factors Regulating or Regulated by Myogenic Regulatory Factors in Skeletal Muscle Stem Cells.Cells · 2022Review
- Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation.Frontiers in cell and developmental biology · 2022Review
- Review
- Elucidating the pathogenic and biomarker potentials of FOXG1 in glioblastoma.Oncology reviews · 2020Article
- Article
- The Wnt Transcriptional Switch: TLE Removal or Inactivation?BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor.The Journal of biological chemistry · 2017Article
- Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.Molecular cell · 2017Article
- Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity.BMC genomics · 2017Article
- Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells.Stem cells international · 2016Review
- The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.The Journal of biological chemistry · 2015Article
- Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.Science advances · 2015Article
- The Groucho co-repressor is primarily recruited to local target sites in active chromatin to attenuate transcription.PLoS genetics · 2014Article
- Molecular functions of the TLE tetramerization domain in Wnt target gene repression.The EMBO journal · 2014Article
- GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.PloS one · 2013Article
- Investigation of dmyc Promoter and Regulatory Regions.Gene regulation and systems biology · 2013Article
- Identification of cis-Regulatory Elements in the dmyc Gene of Drosophila Melanogaster.Gene regulation and systems biology · 2012Article
- Article
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4 authors.
Funding
Abstract
Drosophila Groucho (Gro) is a member of a family of metazoan corepressors with widespread roles in development. Previous studies indicated that a conserved domain in Gro, termed the Q domain, was required for repression in cultured cells and mediated homotetramerization. Evidence presented here suggests that the Q domain contains two coiled-coil motifs required for oligomerization and repression in vivo. Mutagenesis of the putative hydrophobic faces of these motifs, but not of the hydrophilic faces, prevents the formation of both tetramers and higher order oligomers. Mutagenesis of the hydrophobic faces of both coiled-coil motifs in the context of a Gal4-Gro fusion protein prevents repression of a Gal4-responsive reporter in S2 cells, while mutagenesis of a single motif weakens repression. The finding that the repression directed by the single mutants depends on endogenous wild-type Gro further supports the idea that oligomerization plays a role in repression. Overexpression in the fly of forms of Gro able to oligomerize, but not of a form of Gro unable to oligomerize, results in developmental defects and ectopic repression of Gro target genes in the wing disk. Although the function of several corepressors is suspected to involve oligomerization, these studies represent one of the first direct links between corepressor oligomerization and repression in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.