ArticleEnvironmental health perspectives2004
Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Genome-wide association study of blood lead shows multiple associations near ALAD.Human molecular genetics · 2015Pooled it
- Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator TransportInternational journal of environmental research and public health · 2019Article
- Childhood Lead Exposure and Adult Neurodegenerative Disease.Journal of Alzheimer's disease : JAD · 2018Review
- Different People, Different Outcomes: Assessing Genetic Susceptibility to Lead Exposures.Environmental health perspectives · 2016Article
- Variation in an Iron Metabolism Gene Moderates the Association Between Blood Lead Levels and Attention-Deficit/Hyperactivity Disorder in Children.Psychological science · 2016Article
- Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study.PloS one · 2016Article
- Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: The Normative Aging Study.Neurotoxicology · 2015Article
- Effect modification by vitamin D receptor genetic polymorphisms in the association between cumulative lead exposure and pulse pressure: a longitudinal study.Environmental health : a global access science source · 2015Article
- Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study.Environmental health : a global access science source · 2014Article
- Genetic diversity influences the response of the brain to developmental lead exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- The effect of the hemochromatosis (HFE) genotype on lead load and iron metabolism among lead smelter workers.PloS one · 2014Article
- Blood cadmium is elevated in iron deficient U.S. children: a cross-sectional study.Environmental health : a global access science source · 2013Article
- Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat.Environmental geochemistry and health · 2013Article
- Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study.Environmental health : a global access science source · 2013Article
- Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models.Environmental health : a global access science source · 2011Article
- HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging Study.Environmental health perspectives · 2010Article
- HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico.Environmental health : a global access science source · 2010Article
- Bone lead level prediction models and their application to examine the relationship of lead exposure and hypertension in the Third National Health and Nutrition Examination Survey.Journal of occupational and environmental medicine · 2009Article
- Iron metabolism genes, low-level lead exposure, and QT interval.Environmental health perspectives · 2009Article
- Variants in iron metabolism genes predict higher blood lead levels in young children.Environmental health perspectives · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene (HFE) is associated with body lead burden. Patella and tibia lead levels were measured by K X-ray fluorescence in subjects from the Normative Aging Study. DNA samples were genotyped for C282Y and H63D using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP). A series of multivariate linear regression models were constructed with bone or blood lead as dependent variables; age, smoking, and education as independent variables; and C282Y or H63D as independent risk factors and/or effect modifiers. Of 730 subjects, 94 (13%) carried the C282Y variant and 183 (25%) carried the H63D variant. In the crude analysis, mean tibia, patella, and blood lead levels were consistently lower in carriers of either HFE variant compared with levels in subjects with wild-type genotypes. In multivariate analyses that adjusted for age, smoking, and education, having an HFE variant allele was an independent predictor of significantly lower patella lead levels (p < 0.05). These data suggest that HFE variants have altered kinetics of lead accumulation after exposure. Among elderly men, subjects with HFE variants had lower patella lead levels. These effects may be mediated by alterations in lead toxicokinetics via iron metabolic pathways regulated by the HFE gene product and body iron stores.
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