ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Epidermal growth factor receptor expression correlates with histologic grade in resected esophageal adenocarcinoma.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 90 citations in OpenAlex.
- Promising outcomes of definitive chemoradiation and cetuximab for patients with esophageal squamous cell carcinoma.Cancer science · 2012Trial
- Feasibility of chemoradiotherapy for oesophageal cancer in elderly patients aged >or=75 years: a prospective, single-arm phase II study.Drugs & aging · 2009Trial
- Near-Infrared Photoimmunotherapy Targeting Esophagogastric Junction Adenocarcinoma With Fully Human Anti-EpCAM Antibody.Cancer science · 2025Article
- Targeted Molecular Therapies in the Treatment of Esophageal Adenocarcinoma, Are We There Yet?Cancers · 2020Review
- Article
- Targeted Therapies and Immunotherapies in the Treatment of Esophageal Cancers.Medical sciences (Basel, Switzerland) · 2019Review
- EGFR family and cMet expression profiles and prognostic significance in esophagogastric adenocarcinoma.Journal of gastrointestinal oncology · 2016Article
- Assessment of epidermal growth factor receptor mutation/copy number and K-ras mutation in esophageal cancer.Journal of thoracic disease · 2016Article
- Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma.PloS one · 2016Article
- Phosphorylated AKT1 is associated with poor prognosis in esophageal squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2015Article
- Gastric cancer and the epoch of immunotherapy approaches.World journal of gastroenterology · 2015Review
- Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitinib.Langenbeck's archives of surgery · 2014Article
- Clinical significance of the expression of EGFR signaling pathway-related proteins in esophageal squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Gastric cancer-molecular and clinical dimensions.Nature reviews. Clinical oncology · 2013Review
- Expression of epidermal growth factor receptor is an independent prognostic factor for esophageal squamous cell carcinoma.World journal of surgical oncology · 2013Article
- Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction.Cancer biology & therapy · 2013Review
- Increase of epidermal growth factor receptor expression in progression of GERD, Barrett, and adenocarcinoma of esophagus.Digestive diseases and sciences · 2013Article
- Immunotherapy for gastrointestinal malignancies.Cancer control : journal of the Moffitt Cancer Center · 2013Review
- Molecular targeted therapies in advanced gastric cancer: does tumor histology matter?Therapeutic advances in gastroenterology · 2013Article
- New and emerging combination therapies for esophageal cancer.Cancer management and research · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of the epidermal growth factor receptor (EGFR) has a role in oncogenesis and may correlate with prognosis. The aim of this study was to examine EGFR expression in esophageal adenocarcinoma and correlate EGFR status with pathologic and clinical prognostic features. An exploratory retrospective review of 38 patients with surgically resected esophageal adenocarcinoma was performed. All patients underwent an esophagogastrectomy with regional lymphadenectomy; 24 patients underwent primary resection and 14 patients had surgery after preoperative chemoradiation therapy. Immunohistochemical analysis was performed on paraffin-embedded tissue samples using an EGFR monoclonal antibody. Low- and moderate-grade tumors were positive for EGFR expression in 2 of 15 patients; poorly differentiated tumors were positive for EGFR expression in 13 of 23 patients (p=0.02). The median survival was 35 months (confidence interval [CI]: 29-40) for EGFR negative patients (n=23) and 16 months (CI: 10-22) for EGFR positive patients (n=13) (p=0.10). Disease recurred in 3 of 21 EGFR negative patients and 6 of 13 EGFR positive patients (p=0.06). Poorly differentiated adenocarcinomas of the esophagus demonstrated higher EGFR expression compared to low-grade tumors based upon immunohistochemical analysis. A trend toward improved disease-free and overall survival was seen in EGFR negative patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.