ArticleVirchows Archiv : an international journal of pathology2004
Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies.
Article in Virchows Archiv : an international journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Protein expression of PTEN, insulin-like growth factor I receptor (IGF-IR), and lethal prostate cancer: a prospective study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Trial
- Multiscale-omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target.NPJ precision oncology · 2021Article
- Superior cancer preventive efficacy of low versus high dose of mTOR inhibitor in a mouse model of prostate cancer.Oncotarget · 2020Article
- PTEN Tumor-Suppressor: The Dam of Stemness in Cancer.Cancers · 2019Review
- mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy.International journal of molecular sciences · 2019Review
- Vitamin K2, a menaquinone present in dairy products targets castration-resistant prostate cancer cell-line by activating apoptosis signaling.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Effect of p27 gene combined with Pientzehuang ([characters: see text]) on tumor growth in osteosarcoma-bearing nude mice.Chinese journal of integrative medicine · 2015Article
- PTEN genomic deletion defines favorable prognostic biomarkers in localized prostate cancer: a systematic review and meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Targeting the PI3-kinase/Akt/mTOR signaling pathway.Surgical oncology clinics of North America · 2013Review
- Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2012Article
- The AR dependent cell cycle: mechanisms and cancer relevance.Molecular and cellular endocrinology · 2012Review
- Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer.Journal of negative results in biomedicine · 2012Article
- The genomic landscape of prostate cancer.Frontiers in endocrinology · 2012Article
- Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway.Current cancer drug targets · 2009Review
- What is the molecular pathology of low-risk prostate cancer?World journal of urology · 2008Review
- RAD001 (Everolimus) inhibits growth of prostate cancer in the bone and the inhibitory effects are increased by combination with docetaxel and zoledronic acid.The Prostate · 2008Article
- Expression of p27((Kip1)), cyclin D3 and Ki67 in BPH, prostate cancer and hormone-treated prostate cancer cells.International urology and nephrology · 2008Article
- Loss of p27(Kip1) CDKI is a predictor of poor recurrence-free and cancer-specific survival in patients with renal cancer.International urology and nephrology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extreme variability of prostate cancer implies latent disease with missing clinical symptoms in some cases. Tumor suppressors PTEN (phosphatase and tensin homolog deleted on chromosome ten) and p27kip1 are frequently mutated in various human cancers. PTEN negatively influences cell growth and induces apoptosis, while p27kip1 binds to cyclin-E-Cdk2 and counteracts mitosis. This study investigated the expression of PTEN and p27kip1 in prostatectomies and needle biopsies in order to determine whether protein localization or expression levels are correlated with tumor grade and whether PTEN and p27kip1 expression in biopsies are valuable predictive tumor markers. Analysis of PTEN demonstrated that weak expression levels were significantly more prevalent in high-grade tumors. Analysis of p27kip1 revealed that high-grade tumors had a higher percentage of cytoplasmic localization of the protein than low-grade tumors, where nuclear localization was more frequent. Furthermore, this study indicated a positive association between PTEN and p27kip1 levels. An increase of high-grade tumors corresponded to a progressive loss of both tumor suppressors in needle biopsies and prostatectomies. p27kip1 and PTEN did not show a higher predictive accuracy of the tumor grade in the surgical specimen than the Gleason score. However, p27kip1 had the same predictive value as the Gleason score in needle biopsies.
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