ArticleProceedings of the National Academy of Sciences of the United States of America2004
Mechanism of homophilic adhesion by the neural cell adhesion molecule: use of multiple domains and flexibility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Autoantibodies and Inflammation in Schizophrenia.Psychiatry and clinical neurosciences · 2025Review
- Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential.Military Medical Research · 2024Review
- Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice.Cell reports. Medicine · 2022Article
- Cell Communication-mediated Nonself-Recognition and -Intolerance in Representative Species of the Animal Kingdom.Journal of molecular evolution · 2020Review
- EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion.Scientific reports · 2018Article
- Structural Characterization and Function Prediction of Immunoglobulin-like Fold in Cell Adhesion and Cell Signaling.Journal of chemical information and modeling · 2018Article
- Understanding the Functional Roles of Multiple Extracellular Domains in Cell Adhesion Molecules with a Coarse-Grained Model.Journal of molecular biology · 2017Article
- Article
- Regulation of adhesion by flexible ectodomains of IgCAMs.Neurochemical research · 2013Review
- Magnetic tweezers-based force clamp reveals mechanically distinct apCAM domain interactions.Biophysical journal · 2012Article
- Single-molecule force spectroscopy of the Aplysia cell adhesion molecule reveals two homophilic bonds.Biophysical journal · 2012Article
- Neural cell adhesion molecule and its polysialic acid moiety exhibit opposing and linked effects on neuropathic hyperalgesia.Experimental neurology · 2012Article
- Sequences at the interface of the fifth immunoglobulin domain and first fibronectin type III repeat of the neural cell adhesion molecule are critical for its polysialylation.The Journal of biological chemistry · 2011Article
- Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites.The Journal of biological chemistry · 2010Article
- Elasticity and rupture of a multi-domain neural cell adhesion molecule complex.Biophysical journal · 2009Article
- Multiscale modeling of form and function.Science (New York, N.Y.) · 2009Review
- Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule.Journal of molecular biology · 2008Article
- Similarities between heterophilic and homophilic cadherin adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Multiple-bond kinetics from single-molecule pulling experiments: evidence for multiple NCAM bonds.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The extracellular regions of adhesion proteins of the Ig superfamily comprise multiple, tandemly arranged domains. We used directforce measurements to investigate how this modular architecture contributes to the adhesive interactions of the neural cell adhesion molecule (NCAM), a representative of this protein class. The extracellular region of NCAM comprises five immunoglobulin and two fibronectin domains. Previous investigations generated different models for the mechanism of homophilic adhesion that each use different domains. We use force measurements to demonstrate that NCAM binds in two spatially distinct configurations. Igdomain deletion mutants identified the domains responsible for each of the adhesive bonds. The measurements also confirmed the existence of a flexible hinge that alters the orientation of the adhesive complexes and the intermembrane distance. These results suggest that a combination of multiple bound states and internal molecular flexibility allows for sequentially synergistic bond formation and the ability to accommodate differences in intercellular space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.