ArticleNucleic acids research2004
Alpha1-induced DNA bending is required for transcriptional activation by the Mcm1-alpha1 complex.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- The master regulator MAT1-1-1 of fungal mating binds to its targets via a conserved motif in the human pathogen Aspergillus fumigatus.G3 (Bethesda, Md.) · 2021Article
- The TALE face of Hox proteins in animal evolution.Frontiers in genetics · 2015Article
- Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.EMBO molecular medicine · 2014Article
- How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes.Genes & development · 2014Article
- Article
- Mcm1p binding sites in ARG1 positively regulate Gcn4p binding and SWI/SNF recruitment.Biochemical and biophysical research communications · 2009Article
- Interspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts.Genes & development · 2008Article
- Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.Biochimica et biophysica acta · 2007Review
- MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain.Molecular and cellular biology · 2006Article
- Bayesian error analysis model for reconstructing transcriptional regulatory networks.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- N-terminal arm of Mcm1 is required for transcription of a subset of genes involved in maintenance of the cell wall.Eukaryotic cell · 2005Article
- The contribution of phosphate-phosphate repulsions to the free energy of DNA bending.Nucleic acids research · 2005Article
- NFI and Oct-1 bend the Ad5 origin in the same direction leading to optimal DNA replication.Nucleic acids research · 2004Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The yeast Mcm1 protein is a founding member of the MADS-box family of transcription factors that is involved in the regulation of diverse sets of genes through interactions with distinct cofactor proteins. Mcm1 interacts with the Matalpha1 protein to activate the expression of the alpha-cell type-specific genes. To understand the requirement of the cofactor alpha1 for Mcm1-alpha1-dependent transcriptional activation we analyzed the recruitment of Mcm1 to the promoters of alpha-specific genes in vivo and found that Mcm1 is able to bind to the promoters of alpha-specific genes in the absence of alpha1. This suggests the function of alpha1 is more complex than simply recruiting Mcm1. Several MADS-box transcription factors, including Mcm1, induce DNA bending and there is evidence the proper bend may be required for transcriptional activation. We analyzed Mcm1-dependent bending of a Mcm1-alpha1 binding site in the presence and absence of alpha1 and found that Mcm1 alone shows a reduced DNA-bend at this site compared with other Mcm1 binding sites. However, the addition of alpha1 markedly increases the DNA-bend and we present evidence this bend is required for full transcriptional activation. These results support a model in which proper DNA-bending by the Mcm1-alpha1 complex is required for transcriptional activation.
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