ArticleAIDS research and human retroviruses2004
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
Article in AIDS research and human retroviruses, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression.Vaccines · 2022Article
- Novel Nested Peptide Epitopes Recognized by CD4Vaccines · 2020Article
- Possible clearance of transfusion-acquiredJournal of virus eradication · 2019Article
- Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows.Frontiers in immunology · 2018Article
- T-Regulatory Cells and Vaccination "Pay Attention and Do Not Neglect Them": Lessons from HIV and Cancer Vaccine Trials.Vaccines · 2016Review
- A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function.Retrovirology · 2014Article
- Article
- CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller.Retrovirology · 2012Article
- Human CD4+ T cell response to human herpesvirus 6.Journal of virology · 2012Article
- Cross-clade recognition of HIV-1 CAp24 by CD4+ T cells in HIV-1-infected individuals in Burkina Faso and Germany.The open AIDS journal · 2009Article
- Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Advances in FIV vaccine technology.Veterinary immunology and immunopathology · 2008Review
- The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.Journal of virology · 2008Article
- Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection.PLoS pathogens · 2007Article
- Article
- The antigenic determinants on HIV p24 for CD4+ T cell inhibiting antibodies as determined by limited proteolysis, chemical modification, and mass spectrometry.Journal of the American Society for Mass Spectrometry · 2006Article
- Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.Molecular immunology · 2006Article
- HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimulatory microarrays.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Despite growing evidence that HIV-1-specific CD4(+) T helper (Th) cells may play a role in the control of viremia, discrete Th cell epitopes remain poorly defined. Furthermore, it is not known whether Th cell responses generated using vaccines based on clade B virus sequences will elicit immune responses that are effective in regions of the world where non-clade B viruses predominate. To address these issues we isolated CD4(+) T cell clones from individuals with vigorous HIV-1-specific Th cell responses and identified the minimum epitopes recognized. The minimum peptide length required for induction of CD4(+) T cell proliferation, IFN-gamma secretion, and cytolytic activity ranged from 9 to 16 amino acids in the five epitopes studied. Cross-clade recognition of the defined epitopes was examined for variant peptides from clades A, B, C, D, and AE. Over half the variant epitopes (17 of 32) exhibited impaired recognition, defined as less than 50% of the IFN-gamma secretion elicited by B clade consensus sequence. There was no evidence for antagonistic activity mediated by the variant peptides, and despite strong responses there was no escape of autologous virus from Th responses in the epitopes we studied. Abrogated recognition of variant CD4(+) T cell epitopes presents a potential obstacle to vaccine development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.