ArticleOncogene2004
Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- The S100 Protein Family as Players and Therapeutic Targets in Pulmonary Diseases.Pulmonary medicine · 2021Review
- An Overview of the Role of Adipokines in Cardiometabolic Diseases.Molecules (Basel, Switzerland) · 2020Review
- S100 proteins in obesity: liaisons dangereuses.Cellular and molecular life sciences : CMLS · 2020Review
- Screening of potential adipokines identifies S100A4 as a marker of pernicious adipose tissue and insulin resistance.International journal of obesity (2005) · 2018Article
- Article
- The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.Theranostics · 2018Article
- S100A4 protects the myocardium against ischemic stress.Journal of molecular and cellular cardiology · 2016Article
- S100A4 accelerates the proliferation and invasion of endometrioid carcinoma and is associated with the "MELF" pattern.Cancer science · 2016Article
- Tungsten-induced carcinogenesis in human bronchial epithelial cells.Toxicology and applied pharmacology · 2015Article
- S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance.BMC cancer · 2015Article
- Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction.Molecular therapy. Methods & clinical development · 2015Article
- Joining S100 proteins and migration: for better or for worse, in sickness and in health.Cellular and molecular life sciences : CMLS · 2014Review
- Metastasin S100A4 is a mediator of sex hormone-dependent formation of the cortical bone.Molecular endocrinology (Baltimore, Md.) · 2013Article
- The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NFκB through the RAGE Receptor.Genes & cancer · 2013Article
- Anti-S100A4 antibody suppresses metastasis formation by blocking stroma cell invasion.Neoplasia (New York, N.Y.) · 2012Article
- S100A4 in esophageal cancer: is this the one to blame?World journal of gastroenterology · 2012Article
- Article
- Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo.International journal of cancer · 2012Article
- The metastasis-promoting S100A4 protein confers neuroprotection in brain injury.Nature communications · 2012Article
- S100A4 and metastasis: a small actor playing many roles.The American journal of pathology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis-promoting Mts1(S100A4) protein belongs to the S100 family of Ca(2+)-binding proteins. A mouse strain with a germ-line inactivation of the S100A4 gene was generated. The mice were viable and did not display developmental abnormalities in the postnatal period. However, an abnormal sex ratio was observed in the litters with the S100A4-/- genotype, raising the possibility of a certain level of embryonic lethality in this strain. In all, 10% of 10-14-month-old S100A4-null animals developed tumors. This is a characteristic feature of mouse strains with inactivated tumor suppressor genes. Spontaneous tumors of S100A4-/- mice were p53 positive. Recently, we have shown that S100A4 interacts with p53 tumor suppressor protein and induces apoptosis. We proposed that impairment of this interaction could affect the apoptosis-promoting function of p53 that is involved in its tumor suppressor activity. The frequency of apoptosis in the spleen of S100A4-/- animals after whole-body gamma-irradiation was reduced compared to the wild-type animals. The same was true for the transcriptional activation of the p53 target genes - waf/p21/cip1 and bax. Taken together, these observations indicate that spontaneous tumors in S100A4-/- mice are a result of functional destabilization of p53 tumor suppressor gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.