ArticleGenes and immunity2004
Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis.Journal of assisted reproduction and genetics · 2016Pooled it
- Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis.PloS one · 2013Pooled it
- An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.Endocrine · 2011Pooled it
- Postpartum cytokine shifts and IL-10-mediated immune suppression in malaria-infected primigravid women.PloS one · 2026Article
- IL-10 (-1082 G/A) polymorphism in Bataknese with schizophrenia.Journal of Taibah University Medical Sciences · 2024Article
- Differential genotypes of TNF-α and IL-10 for immunological diagnosis in discoid lupus erythematosus and oral lichen planus: A narrative review.Frontiers in immunology · 2022Review
- Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma.African health sciences · 2020Review
- The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy.Journal of inflammation research · 2016Article
- PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Article
- Association between Interleukin-10 gene polymorphisms and risk of early-onset preeclampsia.International journal of clinical and experimental pathology · 2015Article
- Increased serum levels of interleukin-10 predict poor prognosis in extranodal natural killer/T-cell lymphoma patients receiving asparaginase-based chemotherapy.OncoTargets and therapy · 2015Article
- Interleukin 10 gene promoter polymorphisms in women with early-onset pre-eclampsia.Clinical and experimental immunology · 2014Article
- Genetic Variants of Interleukin-10 Gene Promoter are Associated with Schizophrenia in Saudi Patients: A Case-Control Study.North American journal of medical sciences · 2014Article
- Association of the four common polymorphisms in interleukin-10 (rs1800890, rs1800896, rs1800871, and rs1800872) with non-Hodgkin's lymphoma risk: a meta-analysis.International journal of clinical and experimental medicine · 2014Article
- Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma.The oncologist · 2013Article
- What do cytokine profiles tell us about subsets of juvenile idiopathic arthritis?Current rheumatology reports · 2012Review
- Pilot study: possible association of IL10 promoter polymorphisms with CRMO.Rheumatology international · 2012Article
- Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO).International journal of rheumatology · 2012Article
- Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-10 (IL-10), a cytokine involved in many aspects of the immune response shows interindividual variations in their expression. However, genetic variations of the 5'-flanking region of the IL-10 gene (PIL-10) are poorly characterised with respect to different stimuli. New extended haplo- and genotypes are identified present at differing frequencies in three geographically separated populations. Their influence on IL-10 expression have been assessed in vitro after stimulation of leukocytes with lipopolysaccharide (LPS), dibutyryl-cAMP or following immortalisation with Epstein-Barr virus (lymphoblastoid cell line (LCL)). Interindividual differences of IL-10 production were found to be related to single-nucleotide polymorphisms (SNP) haplotype -6752/-6208 in LCLs (P<0.02), and for haplotypes comprising SNPs -6752/-6208/-3538 after LPS stimulation (P<0.03). Carriers of the IL10.G microsatellite with 22, 24 or 26 dinucleotide repeats linked with the -1087G SNP, exhibited the highest levels of IL-10 expression. Contrasting IL-10 secretion patterns were found for IL10.R microsatellite alleles characterised by 15 dinucleotide repeats: after LPS stimulation this allele was associated with high IL-10 production (P<0.007), but with low IL-10 levels in LCLs (P< 0.038). Thus, the effects of mosaics of genetic elements in the PIL-10 on the capacity of leukocytes to produce IL-10 depend on the agent inducing IL-10 expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.