ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 168 citations in OpenAlex.
- Voluntary Exercise and Hippocampal Memory Enhancement: Decoding the Molecular Blueprint.Journal of molecular neuroscience : MN · 2026Review
- Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases.Nature communications · 2026Article
- Calming the Nerves via the Immune Instructive Physiochemical Properties of Self-Assembling Peptide Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Review
- Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning.Frontiers in neuroanatomy · 2022Article
- Influence of pharmacological and epigenetic factors to suppress neurotrophic factors and enhance neural plasticity in stress and mood disorders.Cognitive neurodynamics · 2019Review
- NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders.Neurochemical research · 2018Review
- Quantitative assessment of fibroblast growth factor receptor 1 expression in neurons and glia.PeerJ · 2017Article
- Article
- Identification of novel peptoid agonists of fibroblast growth factor receptor using microarray-based screening.MedChemComm · 2016Article
- Polyclonal neural cell adhesion molecule antibody prolongs the effective duration time of botulinum toxin in decreasing muscle strength.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- The synthetic NCAM mimetic peptide FGL mobilizes neural stem cells in vitro and in vivo.Stem cell reviews and reports · 2014Article
- The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis.Psychological medicine · 2014Article
- Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay.The AAPS journal · 2014Article
- Impact of the neural cell adhesion molecule-derived peptide FGL on seizure progression and cellular alterations in the mouse kindling model.ACS chemical neuroscience · 2014Article
- Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Review
- Molecular and cellular changes in the lumbar spinal cord following thoracic injury: regulation by treadmill locomotor training.PloS one · 2014Article
- NCAM and FGFR1 coexpression and colocalization in renal tumors.International journal of clinical and experimental pathology · 2014Article
- NCAM function in the adult brain: lessons from mimetic peptides and therapeutic potential.Neurochemical research · 2013Review
- An NCAM mimetic, FGL, alters hippocampal cellular morphometry in young adult (4 month-old) rats.Neurochemical research · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural cell adhesion molecule (NCAM) plays a critical role in development and plasticity of the nervous system and is involved in the mechanisms of learning and memory. Here, we show that intracerebroventricular administration of the FG loop (FGL), a synthetic 15 amino acid peptide corresponding to the binding site of NCAM for the fibroblast growth factor receptor 1 (FGFR1), immediately after training rats in fear conditioning or water maze learning, induced a long-lasting improvement of memory. In primary cultures of hippocampal neurons, FGL enhanced the presynaptic function through activation of FGFR1 and promoted synapse formation. These results provide the first evidence for a memory-facilitating effect resulting from a treatment that mimics NCAM function. They suggest that increased efficacy of synaptic transmission and formation of new synapses probably mediate the cognition-enhancing properties displayed by the peptide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.