ArticleNucleic acids research2004
Meiosis-specific yeast Hop1 protein promotes synapsis of double-stranded DNA helices via the formation of guanine quartets.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- The ATPase activity of yeast chromosome axis protein Hop1 affects the frequency of meiotic crossovers.Nucleic acids research · 2025Article
- Divergent Gene Expression Following Duplication of Meiotic Genes in the Stick Insect Clitarchus hookeri.Genome biology and evolution · 2021Article
- Telomere repeat-binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters.The Journal of biological chemistry · 2019Article
- Comparative Genomics Supports Sex and Meiosis in Diverse Amoebozoa.Genome biology and evolution · 2018Article
- Extreme clustering of type-1 NF1 deletion breakpoints co-locating with G-quadruplex forming sequences.Human genetics · 2018Article
- Article
- Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks.Biophysical journal · 2017Article
- Synapsable quadruplex-mediated fibers.Nanoscale research letters · 2013Article
- DNA secondary structures: stability and function of G-quadruplex structures.Nature reviews. Genetics · 2012Review
- G-quadruplexes: from guanine gels to chemotherapeutics.Molecular biotechnology · 2011Review
- G-quadruplexes-novel mediators of gene function.Journal of cardiovascular translational research · 2011Review
- G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae.PLoS computational biology · 2010Article
- Genome-wide analyses of recombination prone regions predict role of DNA structural motif in recombination.PloS one · 2009Article
- Review
- Poly-G/poly-C tracts in the genomes of Caenorhabditis.BMC genomics · 2007Article
- Extension of G-quadruplex DNA by ciliate telomerase.The EMBO journal · 2006Article
- HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis.Cell · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most eukaryotes, genetic exchange between paired homologs occurs in the context of a tripartite proteinaceous structure called the synaptonemal complex (SC). Genetic analyses have revealed that the genes encoding SC proteins are vital for meiotic chromosome pairing and recombination. However, the number, nature and/or the mechanism used by SC proteins to align chromosomes are yet to be clearly defined. Here, we show that Saccharomyces cerevisiae Hop1, a component of SC, was able to promote pairing of double-stranded DNA helices containing arrays of mismatched G/G sequences. Significantly, pairing was rapid and robust, independent of homology in the arms flanking the central G/G region, and required four contiguous guanine residues. Furthermore, data from truncated DNA double helices showed that 20 bp on either side of the 8 bp mismatched G/G region was essential for efficient synapsis. Methylation interference indicated that pairing between the two DNA double helices involves G quartets. These results suggest that Hop1 is likely to play a direct role in meiotic chromosome pairing and recombination by its ability to promote synapsis between double-stranded DNA helices containing arrays of G residues. To our knowledge, Hop1 is the first protein shown to promote synapsis of DNA double helices from yeast or any other organism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.