ArticleBMC microbiology2004
In vitro adhesion and invasion inhibition of Shigella dysenteriae, Shigella flexneri and Shigella sonnei clinical strains by human milk proteins.
Article in BMC microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent-InvasiveFrontiers in cellular and infection microbiology · 2022Article
- Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics.Molecules (Basel, Switzerland) · 2020Article
- Bovine Lactoferrin Pre-Treatment Induces Intracellular Killing of AIEC LF82 and Reduces Bacteria-Induced DNA Damage in Differentiated Human Enterocytes.International journal of molecular sciences · 2019Article
- Shigella infection in children under 5 years old in western French Guiana.Epidemiology and infection · 2018Article
- Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis.International journal of molecular sciences · 2017Review
- Invasion of HEp-2 cells by Shigella spp. isolated from acute pediatric diarrhea.GMS infectious diseases · 2017Article
- Two outer membrane proteins are bovine lactoferrin-binding proteins in Mannheimia haemolytica A1.Veterinary research · 2016Article
- Human milk glycoproteins protect infants against human pathogens.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2013Review
- Adhesion of Diarrheagenic Escherichia coli and Inhibition by Glycocompounds Engaged in the Mucosal Innate Immunity.Biology · 2013Article
- Factors that explain excretion of enteric pathogens by persons without diarrhea.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- Human lactoferrin increases Helicobacter pylori internalisation into AGS cells.World journal of microbiology & biotechnology · 2012Article
- Lactoferrin a multiple bioactive protein: an overview.Biochimica et biophysica acta · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundShigella is the etiological agent of shigellosis, a disease responsible for more than 500,000 deaths of children per year, in developing countries. These pathogens colonize the intestinal colon, invade, spreading to the other enterocytes. Breastfeeding plays a very important role in protecting infants from intestinal infections. Amongst milk compounds, glycosylated proteins prevent the adhesion of many enteropathogens in vitro. The aim of this work was to determine the effect of human milk proteins on the colonization potential of Shigella dysenteriae, S. flexneri and S. sonnei. To fulfill this purpose, pooled milk samples from five donors, were fractionated by gel filtration and affinity chromatography. Using tissue culture, the milk fractions obtained were tested in Shigella adhesion and invasion assays.
resultsOur revealed showed that both adhesion and invasion of Shigella species were inhibited by low concentration of secretory immunoglobulin A, lactoferrin and free secretory component. This work also showed that, these proteins bind to superficial and whole-cell Shigella proteins.
conclusionsOur findings suggest that human milk may act inhibiting adhesion and, consequently, invasion of Shigella, thereafter preventing shigellosis in infants.
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