Evidence map›Paper›PMID 1511499›Full record

ReviewCancer metastasis reviews1992

The role of myosin I and II in cell motility.

A K Wilson, R S Pollenz, R L Chisholm, P de Lanerolle

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. The aerotaxis ofFrontiers in cell and developmental biology · 2023
    Article
  2. Novel role ofCell adhesion & migration · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

A K WilsonDepartment of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago.
R S Pollenz
R L Chisholm
P de Lanerolle
University of Illinois Chicago · USNorthwestern University · US

Funding

MOLECULAR GENETIC ANALYSIS OF MOTILITY: MYOSIN LCSR01GM039264 · NIGMS · NORTHWESTERN UNIVERSITY · PI CHISHOLM, REX L · 1988 to 2002
$1.0M
MYOSIN &THE REGULATION OF SMOOTH MUSCLESR01HL035808 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE LANEROLLE, PRIMAL · 1985 to 1993
–
NHLBI NIH HHS HL 02411NHLBI NIH HHS HL 35808NIGMS NIH HHS GM 39264
6 · The paper itself

Abstract

It has been recognized since the turn of the century that cell motility by non-muscle cells requires virtually continuous restructuring of the cytoskeleton (see refs [1-4]). It is also clear that cell motility requires a mechanism for converting chemical energy into mechanical work. The proteins actin and myosin, two important constituents of the cytoskeleton, have been postulated to act as the chemicomechanical transducer in motile cells. Central to their role as a force generating mechanism in motile cells is the ability of myosin (a) to hydrolyze ATP when it interacts with actin and (b) to form filaments. Recent studies on mammalian cells and on the cellular slime mold Dictyostelium discoideum have shed light and at the same time raised questions regarding the involvement of myosin in cell motility. Moreover, they have demonstrated the presence of two types of myosins, called myosin II and myosin I, that have unique biochemical and regulatory properties and that may play different roles in mediating cell motility. In this chapter we will discuss the properties of these two myosins and then describe what is known about their involvement in Dictyostelium and mammalian cell motility.

Indexed as

ActinsAnimalsCell MovementDictyosteliumMacrophagesModels, BiologicalMyosinsActinsMyosins

Identifiers

PMID1511499
OpenAlexW2092695134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.