Evidence map›Paper›PMID 1511497›Full record

ReviewCancer metastasis reviews1992

Chemotaxis of metastatic tumor cells: clues to mechanisms from the Dictyostelium paradigm.

J Condeelis, J Jones, J E Segall

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Lymphocyte electrotaxis in vitro and in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2008
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J CondeelisDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York.
J Jones
J E Segall
Albert Einstein College of Medicine · US

Funding

SIGNAL TRANSDUCTION AND ACTIN DURING AMOEBOID CHEMOTAXISR01GM038511 · NIGMS · YESHIVA UNIVERSITY · PI CONDEELIS, JOHN S · 1988 to 2008
$2.8M
INTERACTIONS OF ACTIN CYTOSKELETON WITH PLASMA MEMBRANER01GM025813 · NIGMS · YESHIVA UNIVERSITY · PI CONDEELIS, JOHN S · 1985 to 2003
$1.5M
MOLECULAR ANALYSIS OF CHEMOTAXIS IN METASTATIC CELLSR03CA054932 · NCI · YESHIVA UNIVERSITY · PI CONDEELIS, JOHN S · 1991 to 1992
–
NCI NIH HHS R03 CA54932NIGMS NIH HHS GM25813NIGMS NIH HHS GM38511
6 · The paper itself

Abstract

Amoeboid movement, and in some cases, amoeboid chemotaxis, is a key step in tumor metastasis. The high degree of conservation in signal transduction pathways and motile machinery in eukaryotic cells suggests that insights and molecular probes developed from the study of these processes in easily manipulated experimental model systems will be applicable directly to experimentally intractable tumor cells. One such model system, Dictyostelium discoideum, is discussed in terms of the molecular events involved in amoeboid chemotaxis. The application of insights and assays developed with Dictyostelium to early events in the chemotaxis of Lewis lung carcinoma cells is reviewed.

Indexed as

ActinsAmino Acid SequenceAnimalsChemotaxisDictyosteliumGTP-Binding ProteinsModels, BiologicalMolecular Sequence DataMyosinsNeoplasm MetastasisOligopeptidesPseudopodiaReceptors, Cyclic AMPSignal TransductionActinsGTP-Binding ProteinsMyosinsOligopeptidesReceptors, Cyclic AMPvalyl-glycyl-valyl-alanyl-prolyl-glycine

Identifiers

PMID1511497
OpenAlexW2063890725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.