ReviewCancer metastasis reviews1992
Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasis.
Review in Cancer metastasis reviews, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 147 citations in OpenAlex.
- Review
- KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells.Scientific reports · 2024Article
- Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target.Frontiers in oncology · 2024Review
- Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Nasal Turbinate Mesenchymal Stromal Cells Preserve Characteristics of Their Neural Crest Origin and Exert Distinct Paracrine Activity.Journal of clinical medicine · 2021Article
- Postbiotics, Metabolic Signaling, and Cancer.Molecules (Basel, Switzerland) · 2021Review
- Anti-tumor effect of volatile oil fromRSC advances · 2019Article
- A comparative assessment of the effects of integrin inhibitor cilengitide on primary culture of head and neck squamous cell carcinoma (HNSCC) and HNSCC cell lines.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- CCN6-mediated MMP-9 activation enhances metastatic potential of human chondrosarcoma.Cell death & disease · 2018Article
- Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion.The Journal of biological chemistry · 2018Article
- The role of type II transmembrane serine protease-mediated signaling in cancer.The FEBS journal · 2017Review
- CTHRC1 mediates multiple pathways regulating cell invasion, migration and adhesion in glioma.International journal of clinical and experimental pathology · 2017Article
- Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.Journal of human genetics · 2016Article
- Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.Molecular pharmacology · 2016Article
- Cilengitide, a small molecule antagonist, targeted to integrin αν inhibits proliferation and induces apoptosis of laryngeal cancer cells in vitro.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Article
- Augmented expression of urokinase plasminogen activator and extracellular matrix proteins associates with multiple myeloma progression.Clinical & experimental metastasis · 2014Article
- CXCR4/CXCL12 participate in extravasation of metastasizing breast cancer cells within the liver in a rat model.PloS one · 2012Article
- Article
- Clinical significance of pAKT and CD44v6 overexpression with breast cancer.Journal of cancer research and clinical oncology · 2010Article
- Nidogen-2: a new serum biomarker for ovarian cancer.Clinical biochemistry · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The relationship between tumor cell adhesion to the extracellular matrix (ECM) and invasion and metastasis formation is one of the most intensively studied topics in cancer biology within the last 10-15 years. The aberrant molecular relationships between malignant tumor cells and their surrounding ECM have been implicated at virtually every stage of the metastatic process; ranging from steps that involve the local invasion of tumor cells away from the primary tumor to those that are involved in mediating extravasation through microvessel-associated basement membranes at the site(s) of metastasis formation. The complexity of tumor metastasis has required that a reductionist approach be taken in order to identify and relate specific molecular mechanisms involved in tumor cell adhesion to various aspects of tumor metastasis. The intensive research efforts into cell adhesion and tumor cell biology have generated many significant new concepts towards our understanding of the molecular aspects of tumor cell adhesion and metastasis. Our purpose in this article is to briefly summarize the relationship of ECM-stimulated tumor cell adhesion to the processes of tumor cell motility and invasion. This is followed by a discussion of certain aspects of signal transduction pathways that may impact on cell motility, with an emphasis on the relationship between phosphatidylinositol hydrolysis and actin polymerization, as well as certain GTP-binding protein-(G-protein) mediated events that could influence cytoskeletal organization and cell motility. Our emphasis is based on increasing evidence that implicates members of the signal transduction G-proteins in the motility and invasion of many normal and transformed cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.