Trial reportAmerican journal of human genetics2004
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection.
Trial report in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 136 citations in OpenAlex.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia.Nature communications · 2025Article
- Population genomics advances in frontier ethnic minorities in China.Science China. Life sciences · 2025Review
- Hemoglobin Variants as Targets for Stabilizing Drugs.Molecules (Basel, Switzerland) · 2025Review
- A Novel Approach Utilizing Domain Adversarial Neural Networks for the Detection and Classification of Selective Sweeps.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- In vitro delayed response to dihydroartemisinin of malaria parasites infecting sickle cell erythocytes.Malaria journal · 2024Article
- Infectious diseases may have arrested the southward advance of microblades in Upper Palaeolithic East Asia.Proceedings. Biological sciences · 2023Article
- A Deep-Learning Approach for Inference of Selective Sweeps from the Ancestral Recombination Graph.Molecular biology and evolution · 2022Article
- Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia.Scientific reports · 2021Article
- A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against COVID-19.Medical science monitor basic research · 2021Article
- Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde.eLife · 2021Article
- From Summary Statistics to Gene Trees: Methods for Inferring Positive Selection.Trends in genetics : TIG · 2020Review
- Impact of Historic Migrations and Evolutionary Processes on Human Immunity.Trends in immunology · 2019Review
- Hemoglobin E, malaria and natural selection.Evolution, medicine, and public health · 2019Review
- Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children.Blood advances · 2018Article
- Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border.The Journal of infection · 2018Article
- Malaria was a weak selective force in ancient Europeans.Scientific reports · 2017Article
- Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome.Genetic epidemiology · 2017Article
- Article
- Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh.The American journal of tropical medicine and hygiene · 2015Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
The hemoglobin E variant (HbE; ( beta )26Glu-->Lys) is concentrated in parts of Southeast Asia where malaria is endemic, and HbE carrier status has been shown to confer some protection against Plasmodium falciparum malaria. To examine the effect of natural selection on the pattern of linkage disequilibrium (LD) and to infer the evolutionary history of the HbE variant, we analyzed biallelic markers surrounding the HbE variant in a Thai population. Pairwise LD analysis of HbE and 43 surrounding biallelic markers revealed LD of HbE extending beyond 100 kb, whereas no LD was observed between non-HbE variants and the same markers. The inferred haplotype network suggests a single origin of the HbE variant in the Thai population. Forward-in-time computer simulations under a variety of selection models indicate that the HbE variant arose 1,240-4,440 years ago. These results support the conjecture that the HbE mutation occurred recently, and the allele frequency has increased rapidly. Our study provides another clear demonstration that a high-resolution LD map across the human genome can detect recent variants that have been subjected to positive selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.