ArticleJournal of clinical pathology2004
Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia.
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- The Intersection between Immune System and Idiopathic Pulmonary Fibrosis-A Concise Review.Fibrosis (Hong Kong, China) · 2025Article
- Altered expression pattern of immune response-related genes and isoforms in hypersensitivity pneumonitis lung fibroblasts.Scientific reports · 2024Article
- Interstitial Score and Concentrations of IL-4Rα, PAR-2, and MMP-7 in Bronchoalveolar Lavage Fluid Could Be Useful Markers for Distinguishing Idiopathic Interstitial Pneumonias.Diagnostics (Basel, Switzerland) · 2021Article
- Interleukin-13 disrupts type 2 pneumocyte stem cell activity.JCI insight · 2020Article
- TRAIL-Dependent Resolution of Pulmonary Fibrosis.Mediators of inflammation · 2018Article
- HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Identification of Potential Key Long Non-Coding RNAs and Target Genes Associated with Pneumonia Using Long Non-Coding RNA Sequencing (lncRNA-Seq): A Preliminary Study.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model.American journal of respiratory cell and molecular biology · 2014Article
- Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes.Fibrogenesis & tissue repair · 2013Article
- STAT6 and lung inflammation.JAK-STAT · 2013Review
- Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias.The open respiratory medicine journal · 2012Article
- γδ T cells attenuate bleomycin-induced fibrosis through the production of CXCL10.The American journal of pathology · 2011Article
- The effect of interleukin-13 (IL-13) and interferon-γ (IFN-γ) on expression of surfactant proteins in adult human alveolar type II cells in vitro.Respiratory research · 2010Article
- Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma.European respiratory review : an official journal of the European Respiratory Society · 2010Review
- Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function.Journal of Korean medical science · 2009Article
- Pulmonary fibrosis: pathogenesis, etiology and regulation.Mucosal immunology · 2009Review
- TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation.Histochemistry and cell biology · 2008Article
- The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis.Antioxidants & redox signaling · 2008Review
- Obligatory role for interleukin-13 in obstructive lesion development in airway allografts.The American journal of pathology · 2006Article
- Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia.Journal of clinical pathology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSome idiopathic interstitial pneumonias (IIPs) are characterised by fibroproliferation and deposition of extracellular matrix. Because efficacious treatment options are limited, research has been directed towards understanding the cytokine networks that may affect fibroblast activation and, hence, the progression of certain IIPs.
aimsTo examine the expression of interleukin 4 (IL-4), IL-13, and their corresponding receptor subunits in the various forms of IIP and normal patient groups.
methodsMolecular and immunohistochemical analysis of IL-4, interferon gamma (IFNgamma), IL-13, IL-4 receptor (IL-R), and IL-13 receptor subunits in surgical lung biopsies (SLBs) from 39 patients (21 usual interstitial pneumonia (UIP), six non-specific interstitial pneumonia (NSIP), eight respiratory bronchiolitic interstitial lung disease (RBILD), and five normal controls).
resultsMolecular analysis demonstrated that IL-13Ralpha2, IL-13Ralpha1, and IL-4Ralpha were present in a greater proportion of upper and lower lobe biopsies from patients with UIP than patients with NSIP and RBILD. Immunohistochemical analysis of patients with UIP, NSIP, and RBILD revealed interstitial staining for all three receptor subunits, whereas such staining was only seen in mononuclear cells present in normal SLBs. Fibroblastic foci in patients with UIP strongly stained for IL-4Ralpha and IL-13Ralpha2. Localised expression of IL-4Ralpha was also seen in SLBs from patients with NSIP but not in other groups.
conclusionSome histological subtypes of IIP are associated with increased pulmonary expression of receptor subunits responsive to IL-4 and IL-13. These findings may be of particular importance in understanding the pathogenesis of IIP and, more importantly, may provide important novel therapeutic targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.