ArticleBMC physiology2004
Detecting and minimizing zinc contamination in physiological solutions.
Article in BMC physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 88 citations in OpenAlex.
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- Barcoded labels as potential source of zinc contamination in trace metal testing.Journal of mass spectrometry and advances in the clinical lab · 2025Article
- Methods for negating the impact of zinc contamination to allow characterization of positive allosteric modulators of glycine receptors.Frontiers in molecular neuroscience · 2024Article
- Positive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies.Pharmacological reviews · 2022Review
- Differential Effects of Transition Metals on Growth and Metal Uptake for Two DistinctMicrobiology spectrum · 2022Article
- Characterization of the roles of activated charcoal and Chelex in the induction of PrfA regulon expression in complex medium.PloS one · 2021Article
- Selenoprotein P Regulates Synaptic Zinc and Reduces Tau Phosphorylation.Frontiers in nutrition · 2021Article
- Purification of Hibernating and Active C- Ribosomes from Zinc-Starved Mycobacteria.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Stable isotope labeling of metal/metal oxide nanomaterials for environmental and biological tracing.Nature protocols · 2019Article
- Two ABC Transporters and a Periplasmic Metallochaperone Participate in Zinc Acquisition in Paracoccus denitrificans.Biochemistry · 2019Article
- Conservation and diversity of the IrrE/DdrO-controlled radiation response in radiation-resistant Deinococcus bacteria.MicrobiologyOpen · 2017Article
- Interactions between Zinc and Allosteric Modulators of the Glycine Receptor.The Journal of pharmacology and experimental therapeutics · 2017Article
- Differential Effects of Iron, Zinc, and Copper onFrontiers in cellular and infection microbiology · 2017Article
- Identification and characterization of heptapeptide modulators of the glycine receptor.European journal of pharmacology · 2016Article
- Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A.PloS one · 2016Article
- Review: CaThe open neurology journal · 2016Article
- The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μM.Frontiers in molecular neuroscience · 2016Article
- Differential metal content and gene expression in rat left ventricular hypertrophy due to hypertension and hyperactivity.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo explore the role of zinc (Zn) in cellular physiology it is important to be able to control and quantify the level of Zn contamination in experimental solutions. A technique that relies on a Zn-sensitive fluorimetric probe is introduced for measuring Zn concentrations as low as 100 pM. The method depends on the combination of the Zn-probe FluoZin-3 together with a slow Zn-chelator, Ca-EDTA, that reduces the background Zn levels and allows repeated measurements in the same solution.
resultsThe method was used to determine which common labware items could leach Zn into solution. Contamination was predictably found to arise from stainless steel and glass. Perhaps less expectedly it was also introduced by methacrylate cuvettes, plastic tissue culture dishes and other plastic labware. The release of nickel from stainless steel electrodes was also imaged using the fluorescent probe Newport Green.
conclusionZn contamination may arise from rather unexpected sources; it is important that all aspects and components used in the course of an experiment be analyzed for the possibility of introducing contaminants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.