ArticleWorld journal of gastroenterology2004
Dexamethasone and dextran 40 treatment of 32 patients with severe acute pancreatitis.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- Glucocorticoid Treatment in Acute Respiratory Distress Syndrome: An Overview on Mechanistic Insights and Clinical Benefit.International journal of molecular sciences · 2023Review
- Fire in the belly: A scoping review of the immunopathological mechanisms of acute pancreatitis.Frontiers in immunology · 2022Article
- Corticosteroid treatment for acute/acute-on-chronic experimental and naturally occurring pancreatitis in several species: a scoping review to inform possible use in dogs.Acta veterinaria Scandinavica · 2021Article
- Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury.Journal of cellular and molecular medicine · 2021Article
- Fluid resuscitation in acute pancreatitis.World journal of gastroenterology · 2014Review
- Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- The role of hypothalamo-hypophyseal-adrenocortical system hormones in controlling pain sensitivity.Neuroscience and behavioral physiology · 2008Review
- Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimBased on the pathogenesis of severe acute pancreatitis and our experimental studies, to investigate the effect of dexamethasone and dextran in treatment of patients with severe acute pancreatitis.
methodsThirty-two patients with severe acute pancreatitis were treated with 0.5-1 mg/kg per day dexamethasone for 3-5 d, and 500-1,000 mL/d of dextran 40 for 7 d, besides the routine therapy.
resultsAfter 4-8 h of treatment, abdominal pain began to be relieved; range of tenderness began to be localized in 27 patients. They were cured with nonsurgical treatment. Five of them were deteriorated, and treated with surgery. Four patients in this group died.
conclusionDexamethasone and dextran 40 block the pathologic process of severe acute pancreatitis through inhibition of inflammatory mediators and improvement of microcirculation disorders respectively.
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Registered trials
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