ArticleWorld journal of gastroenterology2004
Amino acid uptake in arterio-venous serum of normal and cancerous colon tissues.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review).International journal of molecular medicine · 2025Review
- The impact of metabolic supply lines - and the patterns between them - on the development of distant metastases in 64 women with breast cancer.Oncology letters · 2022Article
- Metabolite biomarker discovery for human gastric cancer using dried blood spot mass spectrometry metabolomic approach.Scientific reports · 2022Article
- Contribution of LAT1-4F2hc in Urological Cancers via Toll-like Receptor and Other Vital Pathways.Cancers · 2022Review
- LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence.Translational oncology · 2021Article
- Physiological and Pathophysiological Roles of Ion Transporter-Mediated Metabolism in the Thyroid Gland and in Thyroid Cancer.OncoTargets and therapy · 2020Review
- The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.International journal of molecular sciences · 2019Review
- Article
- Metabolomic alterations in invasive ductal carcinoma of breast: A comprehensive metabolomic study using tissue and serum samples.Oncotarget · 2018Article
- Perioperative dynamics and significance of amino acid profiles in patients with cancer.Journal of translational medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the difference of amino acid uptake between normal and cancerous colon tissues.
methodsSixteen patients with colon cancer were enrolled in our study. Blood samples were taken during operations, serum amino acid concentrations of blood from cancerous or normal colon were analyzed. Amino acid uptake rate was calculated by the A-V difference and evaluated statistically.
resultsExcept for methionine, the uptake rate of amino acids in cancer was higher than that in normal colon (25.01% vs -2.29%, P<0.01). The amino acid uptake rate did not correlate to the size of tumor mass (P>0.05). There was no statistical significance in the amino acid uptake rate according to the Dukes stage, though it was higher in patients with Dukes stage C or D than that with Dukes stage B (P>0.05).
conclusionAbnormal synthetic metabolism of colon cancer may contribute to its higher amino acid uptake rate than that of normal colon.
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Registered trials
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